Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 350
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.474 0.724 331
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 276
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 251
ELN P15502 elastin 2.3E-14 0.455 0.828 245
NRAS P01111 NRAS proto-oncogene, GTPase enzyme modulator 0.53 0.420 0.690 235
PEX1 O43933 peroxisomal biogenesis factor 1 3.3E-14 0.554 0.655 231
EP300 Q09472 E1A binding protein p300 nucleic acid binding; transcription factor; transferase 1.00 0.489 0.828 215
ERCC6 P0DP91 Q03468 ERCC excision repair 6, chromatin remodeling factor 8.1E-22 0.507 0.690 211
PEX5 P50542 peroxisomal biogenesis factor 5 membrane traffic protein; receptor 1.1E-04 0.555 0.690 206
MED12 Q93074 mediator complex subunit 12 nucleic acid binding; transcription factor 1.00 0.528 0.655 205
POLG P54098 DNA polymerase gamma, catalytic subunit nucleic acid binding; transferase 1.3E-09 0.477 0.724 205
CREBBP Q92793 CREB binding protein nucleic acid binding; transcription factor; transferase 1.00 0.451 0.862 204
FIG4 Q92562 FIG4 phosphoinositide 5-phosphatase 3.3E-34 0.561 0.655 194
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.472 0.724 185
PEX2 P28328 peroxisomal biogenesis factor 2 2.8E-04 0.575 0.621 185
RNU4ATAC RNA, U4atac small nuclear (U12-dependent splicing) 0.577 0.655 184
OFD1 O75665 OFD1, centriole and centriolar satellite protein 0.97 0.547 0.724 179
PIEZO2 Q9H5I5 piezo type mechanosensitive ion channel component 2 2.3E-06 0.573 0.655 179
PEX6 Q13608 peroxisomal biogenesis factor 6 3.7E-05 0.562 0.655 176
RET P07949 ret proto-oncogene 1.00 0.418 0.724 174
DHCR7 Q9UBM7 7-dehydrocholesterol reductase oxidoreductase; receptor 6.7E-12 0.527 0.759 168
RAI1 Q7Z5J4 retinoic acid induced 1 transcription factor 1.00 0.558 0.621 168
KAT6B Q8WYB5 lysine acetyltransferase 6B nucleic acid binding; transcription factor; transferase 1.00 0.565 0.690 167