Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
LMNA P02545 lamin A/C 1.00 0.406 0.724 509
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 374
FLNA P21333 filamin A 1.00 0.456 0.793 373
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 350
FGFR1 P11362 fibroblast growth factor receptor 1 1.00 0.388 0.759 329
GJA1 P17302 gap junction protein alpha 1 cell junction protein 0.14 0.431 0.793 251
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 251
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 238
ZMPSTE24 O75844 zinc metallopeptidase STE24 hydrolase; protease 1.4E-15 0.527 0.690 233
PEX1 O43933 peroxisomal biogenesis factor 1 3.3E-14 0.554 0.655 231
EP300 Q09472 E1A binding protein p300 nucleic acid binding; transcription factor; transferase 1.00 0.489 0.828 215
ERCC6 P0DP91 Q03468 ERCC excision repair 6, chromatin remodeling factor 8.1E-22 0.507 0.690 211
PEX5 P50542 peroxisomal biogenesis factor 5 membrane traffic protein; receptor 1.1E-04 0.555 0.690 206
POLG P54098 DNA polymerase gamma, catalytic subunit nucleic acid binding; transferase 1.3E-09 0.477 0.724 205
CREBBP Q92793 CREB binding protein nucleic acid binding; transcription factor; transferase 1.00 0.451 0.862 204
GBA P04062 glucosylceramidase beta 5.6E-06 0.521 0.724 202
MECP2 P51608 methyl-CpG binding protein 2 nucleic acid binding; transferase 0.78 0.463 0.862 202
PEX2 P28328 peroxisomal biogenesis factor 2 2.8E-04 0.575 0.621 185
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus enzyme modulator 0.71 0.443 0.793 184
RNU4ATAC RNA, U4atac small nuclear (U12-dependent splicing) 0.577 0.655 184
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit nucleic acid binding 1.7E-20 0.447 0.828 179
PIEZO2 Q9H5I5 piezo type mechanosensitive ion channel component 2 2.3E-06 0.573 0.655 179
PEX6 Q13608 peroxisomal biogenesis factor 6 3.7E-05 0.562 0.655 176
CHD7 Q9P2D1 chromodomain helicase DNA binding protein 7 1.00 0.504 0.724 175