Source: CTD_human

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 145
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 109
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 85
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 77
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 77
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 67
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 66
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923 62
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 57
SCN8A Q9UQD0 sodium voltage-gated channel alpha subunit 8 Ion channel 1.00 0.510 0.731 57
CALCA P01258 P06881 calcitonin related polypeptide alpha Signaling 1.6E-02 0.416 0.923 54
TBCD Q9BTW9 tubulin folding cofactor D Cellular structure 1.0E-07 0.599 0.615 53
FASN P49327 fatty acid synthase Enzyme 1.00 0.474 0.846 41
FOXG1 P55316 forkhead box G1 0.94 0.522 0.692 41
LETM1 O95202 leucine zipper and EF-hand containing transmembrane protein 1 Transporter 1.2E-06 0.545 0.692 40
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885 40
VIP P01282 vasoactive intestinal peptide Signaling 4.2E-04 0.437 0.846 39
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846 38
KCNA2 P16389 potassium voltage-gated channel subfamily A member 2 Ion channel 0.91 0.612 0.577 37
PAX6 P26367 paired box 6 1.00 0.450 0.769 37
FOLR1 P15328 folate receptor alpha 0.13 0.522 0.885 34
SCN1A P35498 sodium voltage-gated channel alpha subunit 1 Ion channel 1.00 0.477 0.808 34
GAMT Q14353 guanidinoacetate N-methyltransferase 9.5E-03 0.691 0.269 33
PRKRA O75569 protein activator of interferon induced protein kinase EIF2AK2 Kinase 0.42 0.579 0.615 33