Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 128
ABCB1 P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 1.3E-05 0.371 0.828 65
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 62
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 60
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 57
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 53
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 44
NOS3 P29474 nitric oxide synthase 3 8.9E-07 0.401 0.862 44
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 42
DLG3 Q92796 discs large MAGUK scaffold protein 3 transmembrane receptor regulatory/adaptor protein 1.00 0.575 0.414 42
GDI1 P31150 GDP dissociation inhibitor 1 enzyme modulator; transferase 1.00 0.590 0.448 42
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 41
FKRP Q9H9S5 fukutin related protein 6.3E-05 0.514 0.586 38
HMOX1 P09601 heme oxygenase 1 oxidoreductase 7.9E-03 0.403 0.862 38
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 37
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 37
NOS2 P35228 nitric oxide synthase 2 1.5E-14 0.385 0.931 37
EDN1 P05305 endothelin 1 signaling molecule 0.46 0.417 0.828 36
AGER Q15109 advanced glycosylation end-product specific receptor cell adhesion molecule; receptor 3.4E-16 0.472 0.724 33
ICAM1 P05362 intercellular adhesion molecule 1 3.8E-02 0.386 0.897 31
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha transcription factor 1.00 0.497 0.828 31
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 31
SERPINE1 P05121 serpin family E member 1 enzyme modulator 4.7E-02 0.384 0.793 31
CAT P04040 catalase oxidoreductase 1.9E-10 0.397 0.828 30