Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 23
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 22
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 Kinase 1.7E-15 0.448 0.808 20
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 18
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 17
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 16
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 16
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 16
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 16
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 15
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 15
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 15
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14