Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 45
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 39
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 33
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 33
ATM Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 6.0E-46 0.401 0.862 29
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 29
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 28
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 27
CTNNB1 P35222 catenin beta 1 1.00 0.417 0.759 23
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 1.8E-03 0.352 0.862 22
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 20
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 6.7E-15 0.473 0.690 20
APC P25054 APC, WNT signaling pathway regulator 1.00 0.397 0.828 19
BRCA2 P51587 BRCA2, DNA repair associated nucleic acid binding 5.5E-24 0.426 0.793 17
NRAS P01111 NRAS proto-oncogene, GTPase enzyme modulator 0.53 0.420 0.690 17
STK11 Q15831 serine/threonine kinase 11 0.99 0.467 0.655 17
ATR Q13535 ATR serine/threonine kinase kinase; nucleic acid binding; transferase 1.7E-08 0.486 0.759 16
NOTCH1 P46531 notch 1 1.00 0.415 0.759 16
AKT2 P31751 AKT serine/threonine kinase 2 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.61 0.512 0.655 15
FGFR2 P21802 fibroblast growth factor receptor 2 1.00 0.398 0.759 15
KIT P10721 KIT proto-oncogene receptor tyrosine kinase 0.99 0.394 0.759 15
NOTCH2 Q04721 notch 2 1.00 0.474 0.724 15
BAP1 Q92560 BRCA1 associated protein 1 hydrolase; protease 0.99 0.488 0.586 14
BRCA1 P38398 BRCA1, DNA repair associated ligase 1.8E-28 0.410 0.862 14