Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 225
IL6 P05231 interleukin 6 0.34 0.287 0.966 177
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 171
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 170
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 156
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 149
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 134
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 118
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 111
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 111
CXCL8 P10145 C-X-C motif chemokine ligand 8 signaling molecule 0.342 0.862 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 95
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 95
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 94
IFNG P01579 interferon gamma 0.47 0.323 0.897 91
ICAM1 P05362 intercellular adhesion molecule 1 3.8E-02 0.386 0.897 89
HLA-DRB1 P01911 P01912 P04229 P13760 P13761 P20039 Q29974 Q30134 Q30167 Q5Y7A7 Q95IE3 Q9GIY3 Q9TQE0 major histocompatibility complex, class II, DR beta 1 defense/immunity protein 1.0E-03 0.347 0.897 88
CRP P02741 C-reactive protein 3.7E-03 0.399 0.862 85
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 85
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 84
IGF1 P05019 insulin like growth factor 1 0.29 0.355 0.828 84
IL18 Q14116 interleukin 18 2.9E-02 0.404 0.862 84
TLR4 O00206 toll like receptor 4 5.6E-09 0.359 0.931 84
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 83