Gene Gene Full Name DSI g DPI g pLI Disease Type Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
mutS homolog 2 0.406 0.808 0.90
Hereditary Nonpolyposis Colorectal Cancer
disease 1.000 definitive 0.983 5 0 1993 2020
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
PMS1 homolog 2, mismatch repair system component 0.484 0.808 4.5E-27
Hereditary Nonpolyposis Colorectal Cancer
disease 0.800 definitive 0.979 10 0 1994 2020
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
mutS homolog 6 0.462 0.731 3.7E-05
Hereditary Nonpolyposis Colorectal Cancer
disease 0.800 definitive 0.987 9 0 1988 2020
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
mutL homolog 3 0.582 0.538 4.9E-08
Hereditary Nonpolyposis Colorectal Cancer
disease 0.700 moderate 0.933 6 0 2001 2019
Entrez Id: 22909
Gene Symbol: FAN1
FAN1
FANCD2 and FANCI associated nuclease 1 0.610 0.577 1.7E-25
Hereditary Nonpolyposis Colorectal Cancer
disease 0.500 limited 1.000 4 0 2010 2016
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
mutS homolog 3 0.474 0.769 7.4E-31
Hereditary Nonpolyposis Colorectal Cancer
disease 0.390 limited 0.857 6 0 1996 2018
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
exonuclease 1 0.578 0.692 8.1E-13
Hereditary Nonpolyposis Colorectal Cancer
disease 0.350 disputed 0.778 6 0 2000 2016
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
partner and localizer of BRCA2 0.485 0.769 3.0E-19
Hereditary Nonpolyposis Colorectal Cancer
disease 0.340 limited 1.000 7 0 2013 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
checkpoint kinase 2 0.460 0.808 1.2E-24
Hereditary Nonpolyposis Colorectal Cancer
disease 0.330 limited 1.000 12 0 2003 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
ATM serine/threonine kinase 0.374 0.885 5.6E-47
Hereditary Nonpolyposis Colorectal Cancer
disease 0.330 moderate 1.000 6 0 2005 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
cadherin 1 0.401 0.808 0.15
Hereditary Nonpolyposis Colorectal Cancer
disease 0.320 limited 1.000 6 0 1998 2016
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
cyclin dependent kinase inhibitor 1B 0.409 0.769 0.62
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 8 0 1998 2015
Entrez Id: 580
Gene Symbol: BARD1
BARD1
BRCA1 associated RING domain 1 0.597 0.538 1.4E-24
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 4 0 2001 2016
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1
epoxide hydrolase 1 0.500 0.846 3.2E-09
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 3 0 1994 2015
Entrez Id: 6597
Gene Symbol: SMARCA4
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.450 0.885 1.00
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 2 0 2015 2016
Entrez Id: 64218
Gene Symbol: SEMA4A
SEMA4A
semaphorin 4A 0.569 0.692 1.8E-05
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 2 0 2014 2016
Entrez Id: 6224
Gene Symbol: RPS20
RPS20
ribosomal protein S20 0.610 0.692 2.1E-02
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 2 0 2014 2017
Entrez Id: 64332
Gene Symbol: NFKBIZ
NFKBIZ
NFKB inhibitor zeta 0.674 0.577 1.00
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 1 0 2015 2015
Entrez Id: 7518
Gene Symbol: XRCC4
XRCC4
X-ray repair cross complementing 4 0.528 0.769 8.3E-07
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 1 0 2015 2015
Entrez Id: 5795
Gene Symbol: PTPRJ
PTPRJ
protein tyrosine phosphatase receptor type J 0.606 0.615 1.3E-11
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 limited 1.000 1 0 2017 2017
Entrez Id: 1495
Gene Symbol: CTNNA1
CTNNA1
catenin alpha 1 0.584 0.538 0.97
Hereditary Nonpolyposis Colorectal Cancer
disease 0.300 0 0