Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 Biomarker LHGDN These observations suggested that CA9 might be a marker of clinically important hypoxia. 11705854

2001

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN The SP1/SP3 and hypoxia-response element in the CA9 promoter thus may represent a novel type of enhancer capable of mounting responses to a wider range of hypoxic conditions. 12615703

2003

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN The minimal cell density-dependent region within the CA9 promoter consists of the juxtaposed protected region 1 and hypoxia-response elements. 12154057

2002

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN Taken together, our results suggest that besides the PI3K pathway, the MAPK cascade is involved in the regulation of CA9 gene expression under both hypoxia and high cell density. 15833446

2005

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 Biomarker LHGDN Our findings suggest that hypoxia regulates both expression and activity of CA IX in order to enhance the extracellular acidification, which may have important implications for tumor progression. 15556624

2004

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN In vitro, CA9 expression in cultured cells and culture medium was also induced by hypoxia (P<0.01). 18841153

2008

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN In contrast, coexpression of HIF-1alpha and CAIX in the epithelium in phyllodes tumors points to epithelial hypoxia, most probably caused by relatively distant blood vessels. 16168127

2005

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 Biomarker LHGDN Endogenous hypoxia markers: case not proven! 18290322

2008

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN Because fibrous remodeling of the subepithelium could limit delivery of nutrients and oxygen to the epithelium, we assessed expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and carbonic anhydrase IX (CA IX) as markers of cellular hypoxia. 17674038

2007

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. 12560438

2003