Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5327
Gene Symbol: PLAT
PLAT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. 14512838

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. 23028794

2012

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Proteomic analysis of rat plasma following transient focal cerebral ischemia. 22103620

2011

Entrez Id: 8883
Gene Symbol: NAE1
NAE1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Focal transient ischemia increases APP-BP1 expression in neural progenitor cells. 21386696

2011

Entrez Id: 5074
Gene Symbol: PAWR
PAWR
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. 19352052

2009

Entrez Id: 665
Gene Symbol: BNIP3L
BNIP3L
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. 15902200

2005

Entrez Id: 839
Gene Symbol: CASP6
CASP6
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 3037
Gene Symbol: HAS2
HAS2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats. 11283406

2001

Entrez Id: 1440
Gene Symbol: CSF3
CSF3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression. 15530654

2004

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. 24090950

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD TNFR1 upregulation mediates tolerance after brain ischemic preconditioning. 15647744

2005

Entrez Id: 29924
Gene Symbol: EPN1
EPN1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. 19240038

2009

Entrez Id: 1959
Gene Symbol: EGR2
EGR2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke. 22645329

2012

Entrez Id: 4072
Gene Symbol: EPCAM
EPCAM
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD EGP-314 is expressed differentially in three brain zones at an early time in an experimentally induced ischemia rat model. 15950761

2005

Entrez Id: 3240
Gene Symbol: HP
HP
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Proteomic analysis of rat plasma following transient focal cerebral ischemia. 22103620

2011

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The combination of 31409163

2020

Entrez Id: 203
Gene Symbol: AK1
AK1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD [Comparative proteomic analysis of cerebral cortex between middle cerebral artery occlusion rats and normal controls]. 16468349

2005

Entrez Id: 665
Gene Symbol: BNIP3L
BNIP3L
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Selective inhibition of early--but not late--expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage. 21029239

2011

Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. 23516428

2013

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke. 22133807

2012

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. 19623195

2009

Entrez Id: 27429
Gene Symbol: HTRA2
HTRA2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion. 16978742

2007

Entrez Id: 9892
Gene Symbol: SNAP91
SNAP91
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. 19240038

2009

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The function of the adrenocortical axis in permanent middle cerebral artery occlusion: effect of glucocorticoids on the neurological outcome. 21741032

2011

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Hepcidin is involved in iron regulation in the ischemic brain. 21957487

2011