Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The combination of 31409163

2020

Entrez Id: 6548
Gene Symbol: SLC9A1
SLC9A1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na 31250553

2019

Entrez Id: 84329
Gene Symbol: HVCN1
HVCN1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na 31250553

2019

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury. 28963051

2017

Entrez Id: 10135
Gene Symbol: NAMPT
NAMPT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. 28495827

2017

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Role of glycogen synthase kinase 3 in ischemia-induced blood-brain barrier disruption in aged female rats. 28440874

2017

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. 28886009

2017

Entrez Id: 839
Gene Symbol: CASP6
CASP6
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway. 27152455

2016

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway. 27152455

2016

Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. 25882840

2015

Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. 25882840

2015

Entrez Id: 3662
Gene Symbol: IRF4
IRF4
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke. 25652434

2015

Entrez Id: 2902
Gene Symbol: GRIN1
GRIN1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins. 26674869

2015

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. 25903928

2015

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. 24252362

2014

Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of treatment with low-dose gliclazide in a model of middle cerebral artery occlusion and reperfusion in rats. 24602692

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation. 24916922

2014

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Transcriptomics of post-stroke angiogenesis in the aged brain. 24672479

2014

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Enalapril attenuates ischaemic brain oedema and protects the blood-brain barrier in rats via an anti-oxidant action. 24471927

2014

Entrez Id: 7122
Gene Symbol: CLDN5
CLDN5
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats. 24211797

2014

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. 24583056

2014