Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7428
Gene Symbol: VHL
VHL
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Mapping of the von Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis. 1680799

1991

Entrez Id: 54949
Gene Symbol: SDHAF2
SDHAF2
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Genetic aspects of nonchromaffin paraganglioma. 6286462

1982

Entrez Id: 4149
Gene Symbol: MAX
MAX
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max. 7791753

1995

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. 7824936

1995

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. 8099202

1993

Entrez Id: 54949
Gene Symbol: SDHAF2
SDHAF2
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Analysis of a second family with hereditary non-chromaffin paragangliomas locates the underlying gene at the proximal region of chromosome 11q. 8388849

1993

Entrez Id: 7428
Gene Symbol: VHL
VHL
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Molecular genetic diagnosis of von Hippel-Lindau disease in familial phaeochromocytoma. 8592333

1996

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas. 8825918

1996

Entrez Id: 7428
Gene Symbol: VHL
VHL
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas. 8825918

1996

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. 8918855

1996

Entrez Id: 6392
Gene Symbol: SDHD
SDHD
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Fine mapping of an imprinted gene for familial nonchromaffin paragangliomas, on chromosome 11q23. 8981955

1997

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype. 9012462

1997

Entrez Id: 2668
Gene Symbol: GDNF
GDNF
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Genetic predisposition to phaeochromocytoma: analysis of candidate genes GDNF, RET and VHL. 9215674

1997

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Germline mutation of RET codon 883 in two cases of de novo MEN 2B. 9294615

1997

Entrez Id: 6392
Gene Symbol: SDHD
SDHD
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Repositioning the hereditary paraganglioma critical region on chromosome band 11q23. 10323245

1999

Entrez Id: 7428
Gene Symbol: VHL
VHL
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma. 10458336

1999

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene. 10522989

1999

Entrez Id: 6392
Gene Symbol: SDHD
SDHD
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. 10657297

2000

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B. 10675330

2000

Entrez Id: 6391
Gene Symbol: SDHC
SDHC
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Mutations in SDHC cause autosomal dominant paraganglioma, type 3. 11062460

2000

Entrez Id: 6392
Gene Symbol: SDHD
SDHD
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma. 11156372

2001

Entrez Id: 6392
Gene Symbol: SDHD
SDHD
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene. 11391798

2001

Entrez Id: 6390
Gene Symbol: SDHB
SDHB
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. 11404820

2001

Entrez Id: 6391
Gene Symbol: SDHC
SDHC
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Assignment of PGL3 to chromosome 1 (q21-q23) in a family with autosomal dominant non-chromaffin paraganglioma. 11426453

2001

Entrez Id: 7428
Gene Symbol: VHL
VHL
CUI: C0344456
Disease: Malignant Adrenal Medulla Neoplasm
Malignant Adrenal Medulla Neoplasm
0.300 Biomarker CLINGEN Phaeochromocytoma associated with a de novo VHL mutation as form fruste of von Hippel-Lindau disease. 11475579

2001