Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumours. 14735189

2004

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN We show that tumors that constitutively express VEGF-A present with different vascular beds than tumors in which VEGF-A is expressed as a response to central hypoxia. 16804907

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Thus, in progressive but not in stable proteinuric kidney disease, human PTECs show an attenuated VEGF-A expression despite an activation of intracellular hypoxia response and VEGF signaling pathways, which might be due to a reduced expression of positive coregulators, such as EGF and IGF-1. 19139726

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN We reported previously that fludarabine inhibited expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human ovarian cancer cells. 17961496

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN To study the relationship between hypoxia or epidermal growth factor (EGF) and the overexpression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) and the signal transduction pathway of the transcription of VEGF in hepatoma cells. 15040022

2004

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Here we report an RNA switch in human vascular endothelial growth factor-A (VEGFA, also known as VEGF) mRNA 3' untranslated region (UTR) that integrates signals from interferon (IFN)-gamma and hypoxia to regulate VEGFA translation in myeloid cells. 19098893

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis. 18655183

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. 16278385

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN We also found that hypoxia-stimulated VEGF promoter activity and secretion was reduced in cells containing reduced amounts of endogenous BRCA1 protein (obtained by transfecting with BRCA1 siRNAs). 16543242

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN The expression of hypoxia-inducible factor-1alpha (HIF-1alpha), a transcriptional activator of VEGF, was examined by RT-PCR, real-time PCR and western blotting; and the binding of HIF-1alpha to the promoter region of VEGF gene by chromatin immunoprecipitation (ChIP) assay. 17889387

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN Wistar rats (1-day old) were subjected to hypoxia and the periventricular white matter (corpus callosum) was examined for the mRNA and protein expression of hypoxia-inducible factor-1alpha (HIF-1alpha), endothelial, neuronal and inducible nitric oxide synthase (eNOS, nNOS and iNOS), vascular endothelial growth factor (VEGF) and N-methyl-D-aspartate receptor subunit 1 (NMDAR1) between 3 h and 14 days after hypoxic exposure by real-time RT-PCR, western blotting and immunohistochemistry. 16787408

2006