Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy. 22473220

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.280 Biomarker RGD CRF rats showed increased plasma IL-1 alpha, IL1-beta, IL-6, TNF-alpha, and sICAM-1 levels and decreased anti-inflammatory cytokines IL-4 and 10 levels, hypertension, and dyslipidemia. 20199183

2010

Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD CYP1A1 and CYP3A2 protein expression was considerably reduced (>40%, P < 0.001) in rats with CRF. 12039987

2002

Entrez Id: 3990
Gene Symbol: LIPC
LIPC
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone. 8636395

1996

Entrez Id: 3931
Gene Symbol: LCAT
LCAT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.220 Biomarker RGD ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure. 15280162

2004

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Although compelling evidence of a beneficial effect exists for the use of angiotensin-converting enzyme inhibitors (ACEIs) and low-protein diets, there is little evidence on whether carbon adsorbent has an effect on retardation of the progression of CRF. 14586729

2003

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Therapeutic RGD An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. 26903149

2016

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Angiogenic effect of endothelial progenitor cells transfected with telomerase reverse transcriptase on peritubular microvessel in five out of six subtotal nephrectomy rats. 23013219

2012

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. 12089373

2002

Entrez Id: 186
Gene Symbol: AGTR2
AGTR2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. 12089373

2002

Entrez Id: 729
Gene Symbol: C6
C6
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 ModifyingMutation RGD C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. 11912252

2002

Entrez Id: 55328
Gene Symbol: RNLS
RNLS
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Catecholamines regulate the activity, secretion, and synthesis of renalase. 18299506

2008

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.530 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 79602
Gene Symbol: ADIPOR2
ADIPOR2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Compared to the controls, the CRF group exhibited severe hypertriglyceridemia, significant reduction of the skeletal muscle, myocardium and adipose tissue LPL mRNA and protein abundance. 22009636

2012

Entrez Id: 9817
Gene Symbol: KEAP1
KEAP1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.230 Therapeutic RGD Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. 23174956

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.280 Biomarker RGD Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. 22031851

2012

Entrez Id: 4976
Gene Symbol: OPA1
OPA1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Therapeutic RGD Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. 27801955

2017

Entrez Id: 55669
Gene Symbol: MFN1
MFN1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Therapeutic RGD Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. 27801955

2017

Entrez Id: 51024
Gene Symbol: FIS1
FIS1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. 27801955

2017

Entrez Id: 10059
Gene Symbol: DNM1L
DNM1L
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. 27801955

2017

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.230 Therapeutic RGD Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model. 22427849

2012