Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Protein expression of Pgp, MRP2, and MRP3 were reduced by more than 40% (p < 0.01) in CRF rats, whereas Oatp2 and Oatp3 expression remained unchanged. 17135344

2007

Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Pgp and MRP2 activities were decreased by 30 and 25%, respectively, in CRF rats compared with control (p < 0.05). 17135344

2007

Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Protein expression of Pgp, MRP2, and MRP3 were reduced by more than 40% (p < 0.01) in CRF rats, whereas Oatp2 and Oatp3 expression remained unchanged. 17135344

2007

Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. 19878707

2010

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Although compelling evidence of a beneficial effect exists for the use of angiotensin-converting enzyme inhibitors (ACEIs) and low-protein diets, there is little evidence on whether carbon adsorbent has an effect on retardation of the progression of CRF. 14586729

2003

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.530 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 79602
Gene Symbol: ADIPOR2
ADIPOR2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. 12089373

2002

Entrez Id: 186
Gene Symbol: AGTR2
AGTR2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. 12089373

2002

Entrez Id: 384
Gene Symbol: ARG2
ARG2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. 16809898

2006

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.220 Therapeutic RGD Epoetin delta as an antifibrotic agent in the remnant kidney rat: a possible role for transforming growth factor beta and hepatocyte growth factor. 20424483

2010

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2013

Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Serum osteocalcin and to a lesser extend tartrate-resistant acid phosphatase and urinary pyridinoline and deoxypyridinoline crosslinks were higher in the CRF animals compared to the shams, particularly in the animals of the HPD group with more pronounced CRF. 17365904

2007

Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2013

Entrez Id: 729
Gene Symbol: C6
C6
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 ModifyingMutation RGD C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. 11912252

2002

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 873
Gene Symbol: CBR1
CBR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Effect of experimental kidney disease on the functional expression of hepatic reductases. 25332430

2015

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker RGD Our findings indicate localized expression of MCP-1 in proximal tubular cells in the remnant kidney and suggest that MCP-1 in proximal tubular cells is involved in tubulointerstitial damage in chronic kidney failure associated with glomerular hypertension. 12080327

2002

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Sedentary CRF rats exhibited azotemia, hypertension, anemia, oxidative stress, activation of NF-kappaB and upregulations of reactive oxygen species-generating enzyme, NAD(P)H oxidase, MCP-1, cyclooxygenase-2 (COX-2), and PAI-1 in LV. 18797164

2009

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.220 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.260 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 1191
Gene Symbol: CLU
CLU
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. 24325231

2014

Entrez Id: 1535
Gene Symbol: CYBA
CYBA
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.550 Biomarker RGD Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110

2009

Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Biomarker RGD Renal tissue abundance of gp91(phox) subunit of NAD(P)H oxidase was elevated in the untreated CRF group and was partially reduced in the iron dextran-treated CRF group. 15550752

2005