Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. 18067895

2008

Entrez Id: 4973
Gene Symbol: OLR1
OLR1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker LHGDN 3'UTR/T polymorphism of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is associated with modified anti-platelet activity of atorvastatin in hypercholesterolemic subjects. 16285995

2005

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN IL-6 was associated with increased atherosclerosis when the control group was compared with the group free of subclinical CVD. 12482836

2002

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Apolipoprotein E: possible therapeutic target for atherosclerosis. 12769659

2001

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. 14744975

2004

Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker LHGDN Serum albumin predicts cardiac adverse events in patients with advanced atherosclerosis - interrelation with traditional cardiovascular risk factors. 14983239

2004

Entrez Id: 4973
Gene Symbol: OLR1
OLR1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 AlteredExpression LHGDN LOX-1 is upregulated in aortas of diabetic rats and thus may contribute to the pathogenesis of human diabetic atherosclerosis. 15001526

2004

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Tumor necrosis factor (TNF)-alpha-induced endothelial injury, which is associated with atherosclerosis, is mediated by intracellular reactive oxygen species. 16224057

2005

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker LHGDN TLR2 and TLR4 agonists are thought to have a significant role in diseases such as atherosclerosis and DIC, but our research suggests that this is through a mechanism other than direct platelet activation or by modification of platelet responses to other agonists. 16270639

2005

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN PON1 activity, plasma lipids, the titer of autoantibodies against malondialdehyde (MDA)-modified LDL, and atherosclerosis in AdPON1 mice were compared with these in mice that received a control recombinant adenovirus (AdRR5). 16627808

2006

Entrez Id: 820
Gene Symbol: CAMP
CAMP
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.060 AlteredExpression LHGDN LL-37 is produced in atherosclerotic lesions, where it may function as an immune modulator by activating adhesion molecule and chemokine expression, thus enhancing innate immunity in atherosclerosis. 16645154

2006

Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker LHGDN LPL may influence atherosclerosis risk through pleiotropic effects on each aspect of the metabolic syndrome. 16755277

2007

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.030 GeneticVariation LHGDN Factor V (Leiden) mutation may influence the progression of atherosclerosis and the development of restenosis after revascularization in patients with accelerated femoropopliteal atherosclerosis. 17126308

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Vascular endothelial growth factor (VEGF) has been noted in the pathogenesis of atherosclerosis. 17141247

2007

Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 AlteredExpression LHGDN UCP-2 can possibly modify atherosclerotic processes initiated in vascular cells and agents that increase UCP-2 expression in vascular cells may help prevent the development and progression of atherosclerosis in patients with diabetes or hypertension. 17462780

2007

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Adiponectin (APN) secreted from adipocytes is also one of the important molecules to inhibit the development of atherosclerosis. 17521614

2007

Entrez Id: 9446
Gene Symbol: GSTO1
GSTO1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.010 GeneticVariation LHGDN GSTO1 Asp/Asp carriers showed larger areas of atherosclerosis plaques containing interleukin-1 alpha-positive material than carriers of the GSTO1 Ala-allele. 17717316

2007

Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.010 GeneticVariation LHGDN CYP2C19*3 heterozygote alleles are more frequent in patients than in controls (10.2%, 5.6% respectively) and it is related with a three-fold risk of atherosclerosis (odds ratio (OR) = 3.75, confidence interval (CI) = 0.75-18.65). 17868191

2008

Entrez Id: 7391
Gene Symbol: USF1
USF1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.080 GeneticVariation LHGDN USF1 may influence mortality through pathways distinct from atherosclerosis. 17885212

2007

Entrez Id: 114882
Gene Symbol: OSBPL8
OSBPL8
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.010 Biomarker LHGDN ORP8 may, thus, modulate the development of atherosclerosis. 17991739

2008

Entrez Id: 5196
Gene Symbol: PF4
PF4
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker LHGDN CXCL4 in atherosclerosis: possible roles in monocyte arrest and macrophage foam cell formation. 18000592

2007

Entrez Id: 56729
Gene Symbol: RETN
RETN
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 AlteredExpression LHGDN Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis in rodents, while its role in humans is unclear. 18023360

2007

Entrez Id: 55829
Gene Symbol: SELENOS
SELENOS
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.020 Biomarker LHGDN SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis. 18710632

2008

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.260 Biomarker LHGDN Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis. 18763039

2008

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN A lack of increase in high molecular weight-adiponectin in macroalbuminuric subjects with metabolic syndrome may exert renal and atherosclerotic risks. 18006102

2008