Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 Biomarker LHGDN These observations suggested that CA9 might be a marker of clinically important hypoxia. 11705854

2001

Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 Biomarker LHGDN Transfection of MKN28 cells with a dominant-negative PKC-epsilon blocked the induction of GRP78 through ERK by hypoxia, indicating that PKC-epsilon directly participated in GRP78 induction under hypoxia. 11719466

2001

Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 AlteredExpression LHGDN The sequential activation and repression of the human PDGF-B gene during chronic hypoxia reveals antagonistic roles for the depletion of oxygen and glucose. 11811779

2001

Entrez Id: 1958
Gene Symbol: EGR1
EGR1
CUI: C0003130
Disease: Anoxia
Anoxia
0.310 AlteredExpression LHGDN Also, introduction of an antisense oligonucleotide for Egr-1 diminishes EGFR expression during hypoxia, indicating that the up-regulation of EGFR by hypoxia is mediated through Egr-1. 11830539

2002

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Transfection experiments in HepG2 cells showed that both hypoxia and overproduction of HIF-1alpha specifically repressed the transcriptional activity of the rat afp regulatory region through the sequence 5'-CACGTGGG-3' located at -3625 to -3619. 11861398

2002

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0003130
Disease: Anoxia
Anoxia
0.020 AlteredExpression LHGDN Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc. 11861398

2002

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 AlteredExpression LHGDN Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc. 11861398

2002

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN First, HIF-1 controls the expression of gene products that stimulate angiogenesis, such as vascular endothelial growth factor, and promote metabolic adaptation to hypoxia, such as glucose transporters and glycolytic enzymes, thus providing a molecular basis for involvement of HIF-1 in tumor growth and angiogenesis. 11868612

2002

Entrez Id: 2056
Gene Symbol: EPO
EPO
CUI: C0003130
Disease: Anoxia
Anoxia
0.060 AlteredExpression LHGDN Although the DN patients have inappropriately low EPO levels for the severity of their anaemia, they can mount an appropriate EPO response to moderate hypoxia. 11869305

2002

Entrez Id: 2056
Gene Symbol: EPO
EPO
CUI: C0003130
Disease: Anoxia
Anoxia
0.060 AlteredExpression LHGDN Serum erythropoietin concentration increased significantly from 9.5 +/- 3.51 to 33.6 +/- 11.64 U L(-1) (P < 0.05) after 2 days of hypoxia.Thereafter, s-[epo] decreased. 11906321

2002

Entrez Id: 2056
Gene Symbol: EPO
EPO
CUI: C0003130
Disease: Anoxia
Anoxia
0.060 Biomarker LHGDN Taken together, our in-vivo results do not support a gross modulatory effect of a short-term treatment with radical scavenging agents on EPO-production during or after hypoxia in humans, as derived from the detected changes of MDA-concentrations in peripheral plasma. 11906322

2002

Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 AlteredExpression LHGDN In this study, we show that expression of NERF2 was increased under hypoxia and that this increase temporally correlated with the increase in Tie2 expression. 11967990

2002

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Overexpression of HIF-1alpha and HIF-2alpha was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1alpha, P = 0.023; HIF-2alpha, P = 0.013). 11980639

2002

Entrez Id: 3778
Gene Symbol: KCNMA1
KCNMA1
CUI: C0003130
Disease: Anoxia
Anoxia
0.020 Biomarker LHGDN Thus, since regulation was observed in excised patches, maxi-K channel inhibition by hypoxia does not require soluble intracellular components and, mechanistically, is voltage independent and Ca2+i sensitive. 11986367

2002

Entrez Id: 7428
Gene Symbol: VHL
VHL
CUI: C0003130
Disease: Anoxia
Anoxia
0.030 Biomarker LHGDN VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells. 12036906

2002

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 Biomarker LHGDN This suggests a model whereby in some kidney cell types, pVHL may regulate a proliferative response to hypoxia, whereas the loss of pVHL leads to constitutively elevated cyclin D1 and abnormal proliferation under normal growth conditions. 12036906

2002

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0003130
Disease: Anoxia
Anoxia
0.030 AlteredExpression LHGDN Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. 12050157

2002

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003130
Disease: Anoxia
Anoxia
0.020 AlteredExpression LHGDN Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. 12050157

2002

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 AlteredExpression LHGDN Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. 12050157

2002

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to oxygen lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 glucose transporter. 12062197

2002

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Gel shift assays with a (32)P-labeled leptin promoter -116/HRE probe and nuclear extracts from hypoxia-treated cells indicated binding of the HIF1alpha/beta heterodimer, which was blocked with an excess of unlabeled -116/HRE probe or a HIF1-binding probe from the erythropoietin gene enhancer. 12084725

2002

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0003130
Disease: Anoxia
Anoxia
0.020 AlteredExpression LHGDN Taken together, these observations demonstrate that the leptin gene is actively engaged by hypoxia through a transcriptional pathway commonly utilized by hypoxia-sensitive genes. 12084725

2002

Entrez Id: 860
Gene Symbol: RUNX2
RUNX2
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 AlteredExpression LHGDN These data indicate that Runx2 expression in osteoblasts is reduced by hypoxia, and may be a mechanism of osteoporosis by decreased vascular supply. 12088880

2002

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN The minimal cell density-dependent region within the CA9 promoter consists of the juxtaposed protected region 1 and hypoxia-response elements. 12154057

2002

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Transcription of the gene coding for the tumor-associated antigen MN/carbonic anhydrase IX (CAIX) is regulated by hypoxia-inducible factor 1 (HIF-1). 12154057

2002