Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.500 Biomarker PSYGENET 47 patients with Major Depressive Disorder, treated with V 75 - 300 mg/day, underwent CYP2D6 genotyping using the INFINITI-CYP2D6 assay. 24660534

2014

Entrez Id: 4128
Gene Symbol: MAOA
MAOA
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET 94 patients of Caucasian descent with major depressive disorder (f = 61; DSM-IV) were analyzed for DNA methylation status at 43 MAO-A CpG sites via direct sequencing of sodium bisulfite treated DNA extracted from blood cells. 24809685

2015

Entrez Id: 2332
Gene Symbol: FMR1
FMR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker PSYGENET Major depression in females with the FMR1 premutation may not be characterized as an episodically chronic recurrent disorder as it is in community samples and may have a genetic basis given the relationship with CGG repeat length and lack of association with all child and most demographic factors. 18553360

2009

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker PSYGENET Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population. 15296827

2004

Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 Biomarker PSYGENET Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems. 16231040

2006

Entrez Id: 4929
Gene Symbol: NR4A2
NR4A2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker PSYGENET Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls. 16631355

2006

Entrez Id: 64077
Gene Symbol: LHPP
LHPP
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.340 Biomarker PSYGENET LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations. 18268499

2009

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.340 Biomarker PSYGENET S100B rs9722 C > T polymorphism appears not to be an important factor in susceptibility to MDD in a Chinese population. 18939940

2008

Entrez Id: 6303
Gene Symbol: SAT1
SAT1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 Biomarker PSYGENET SAT1 cortical expression levels were also found to be significantly lower in an independent sample of German subjects with major depression who died by suicide in comparison with controls. 19152344

2009

Entrez Id: 9641
Gene Symbol: IKBKE
IKBKE
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 Biomarker PSYGENET IKBKE emerged as a candidate for further studies of genetic factors associated with panic disorder and major depressive disorder. 19786281

2010

Entrez Id: 10270
Gene Symbol: AKAP8
AKAP8
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker PSYGENET AKAP95 pathway and pantothenate and CoA biosynthesis were unique to MD. 19834500

2009

Entrez Id: 5116
Gene Symbol: PCNT
PCNT
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 Biomarker PSYGENET Pericentrin (PCNT) also interacts with DISC1 and recently single-nucleotide polymorphisms (SNPs) within the PCNT gene have been found to show significant associations with SZ and MDD. 19937158

2010

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Serotonin receptor 2C (HTR2C) has been postulated as being involved in the etiology or pathophysiology of mental disorders such as bipolar disorder, major depression and schizophrenia. 20015120

2010

Entrez Id: 6586
Gene Symbol: SLIT3
SLIT3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker PSYGENET SLIT3 duplication is a novel association which explains a definitive proportion of the largely unknown etiology of MDD. 21152026

2010

Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker PSYGENET CYP2C9, CYP2C19 and CYP2D6 genotypes and clinical data were obtained for 150 consecutive, consenting hospital admissions with a diagnosis of major depressive disorder and who were treated with psychotropic medications. 21861666

2011

Entrez Id: 655
Gene Symbol: BMP7
BMP7
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker PSYGENET BMP7 has unique developmental and trophic actions on catecholamine neurons and these findings suggest that reduced astrocyte support for pontine LC neurons may contribute to pathology of brain noradrenergic neurons in MDD. 21896235

2012

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker PSYGENET DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. 23683269

2013

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder. 23706899

2013

Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker PSYGENET TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder. 24549102

2014

Entrez Id: 100302259
Gene Symbol: MIR1202
MIR1202
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 Biomarker PSYGENET miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment. 24908571

2014

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Disrupted in schizophrenia 1 (DISC1) is a risk factor for a spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder. 25272038

2014

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression. 25487992

2014

Entrez Id: 2915
Gene Symbol: GRM5
GRM5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker PSYGENET A comprehensive understanding of mGluR5 regulation in major depression, particularly in comparison to schizophrenia, is crucial as this has extensive implications for mGluR5 targeting novel therapeutics, especially considering that opposing modulation of mGluR5 is of therapeutic interest for these two disorders. 24472577

2014

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.360 Biomarker PSYGENET A follow-up case-control association study of tractable (druggable) genes in recurrent major depression. 21630437

2011

Entrez Id: 27445
Gene Symbol: PCLO
PCLO
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.500 Biomarker PSYGENET A genome-wide association study implicated the polymorphism rs2522833 in the piccolo (PCLO) gene--involved in monoaminergic neurotransmission--as a risk factor for MDD. 22832909

2012