Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6667
Gene Symbol: SP1
SP1
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 AlteredExpression LHGDN Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. 12682078

2003

Entrez Id: 6667
Gene Symbol: SP1
SP1
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 Biomarker LHGDN Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease. 15180327

2004

Entrez Id: 6667
Gene Symbol: SP1
SP1
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 AlteredExpression LHGDN Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer. 12615703

2003

Entrez Id: 6667
Gene Symbol: SP1
SP1
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 Biomarker LHGDN Multiple levels of analysis, including site-directed mutagenesis, chromatin immunoprecipitation, and inhibition by antisense, revealed a critical role for transcription-factor Sp1 in hypoxia-induction of CD39. 18812468

2009

Entrez Id: 6667
Gene Symbol: SP1
SP1
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 AlteredExpression LHGDN In this work we demonstrated, for the first time, that Bcl-2 overexpression in cancer cells exposed to hypoxia modulates urokinase plasminogen activator receptor (uPAR) expression through Sp1 transcription factor and that the extracellular signal-regulated kinase (ERK) pathway plays a role in Sp1 transcriptional activity. 14660675

2004