Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. 22222462

2012

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD. 17943025

2008

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET We here report analysis of data from GENDEP, a part-randomized pharmacogenomic trial, on the outcome of 811 subjects with major depression undergoing treatment with either escitalopram or nortriptyline in which the C825T SNP and three further SNPs in GNB3 were genotyped. 20826553

2011

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression. 18325652

2008

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET These results provide novel evidence suggesting genetic variation in the 5-prime region of GNB3 moderates depressive symptom trajectories among primary care attendees. 24882179

2014