Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET This analysis suggests that DNA hypomethylation of the 5-HTT transcriptional control region - possibly via increased serotonin transporter expression and consecutively decreased serotonin availability - might impair antidepressant treatment response in Caucasian patients with MDD. 24679990

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET This review highlights some research studying changes in the epigenetic patterns intrinsic to genes of 5-HTT and BDNF, which are related to lifelong environmental adversities, which in turn increases the risks of developing MDD. 24972302

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET We therefore investigated whether variation in hippocampus, amygdala, orbitofrontal cortex (OFC) and anterior cingulate cortex volumes at age 12 years mediated a putative association between 5-HTTLPR genotype and first onset of major depressive disorder (MDD) between age 13-19 years, in a longitudinal study of 174 adolescents (48% males). 25226554

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Our study included 2679 participants.Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). 25510949

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET182C) polymorphisms are associated with susceptibility and treatment response in major depressive disorder (MDD). 25650523

2015