Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1
Gene Symbol: A1BG
A1BG
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.010 AlteredExpression LHGDN Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. 18706098

2008

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation LHGDN Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease. 16784755

2006

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation LHGDN These results indicated that A2M-D allele was probably a weak AD protective factor, and there was a possible interaction of APOE-epsilon 4 and A2M-G alleles to increase AD risk in Mainland Han Chinese. 14675603

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker LHGDN Through combination-analysis of the data about the A2M-I/D and the A2M-Ile1000Val variants, the A2M gene was suggested to be associated with Alzheimer's disease. 15931081

2005

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation LHGDN Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy. 12221172

2002

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.020 GeneticVariation LHGDN Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. 18382889

2008

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.020 AlteredExpression LHGDN Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis. 15511627

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.010 GeneticVariation LHGDN Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. 18382889

2008

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0030305
Disease: Pancreatitis
Pancreatitis
0.010 AlteredExpression LHGDN Structural evaluation of plasma alpha2-macroglobulin in acute pancreatitis. 16232083

2005

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.010 AlteredExpression LHGDN Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 15908432

2005

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0040038
Disease: Thromboembolism
Thromboembolism
0.010 AlteredExpression LHGDN In the group of patients (IS n = 103; DVT n = 92), the risk of symptomatic thromboembolism was significantly increased with elevated alpha2MG levels, with a gradual increase per mg dL(-1). 17403113

2007

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0042024
Disease: Urinary Incontinence
Urinary Incontinence
0.010 AlteredExpression LHGDN Is alpha2-macroglobulin important in female stress urinary incontinence? 18077315

2008

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C2937421
Disease: Prostatic Hyperplasia
Prostatic Hyperplasia
0.010 AlteredExpression LHGDN Alpha(2) macroglobulin, a PSA binding protein, is expressed in human prostate stroma. 15611997

2005

Entrez Id: 53947
Gene Symbol: A4GALT
A4GALT
CUI: C0019061
Disease: Hemolytic-Uremic Syndrome
Hemolytic-Uremic Syndrome
0.010 AlteredExpression LHGDN To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter. 18757779

2008

Entrez Id: 53947
Gene Symbol: A4GALT
A4GALT
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins. 11782470

2002

Entrez Id: 51146
Gene Symbol: A4GNT
A4GNT
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.010 AlteredExpression LHGDN Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. 16441422

2006

Entrez Id: 8086
Gene Symbol: AAAS
AAAS
CUI: C0001623
Disease: Adrenal gland hypofunction
Adrenal gland hypofunction
0.140 Biomarker LHGDN Triple A syndrome. 19011813

2008

Entrez Id: 132949
Gene Symbol: AASDH
AASDH
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.010 AlteredExpression LHGDN Cloning and characterization of a novel human homolog* of mouse U26, a putative PQQ-dependent AAS dehydrogenase. 15865210

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease
1.000 GeneticVariation LHGDN We propose that patients with apparently isolated HDL deficiency who are found to carry ABCA1 mutations may in fact belong to a category of TD patients whose phenotypic features are only partially expressed, and that a number of hidden clinical variants of TD might exist among other HDL deficiency patients who have escaped correct clinical diagnosis. 12111371

2002

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease
1.000 GeneticVariation LHGDN Abnormal splicing of ABCA1 pre-mRNA in Tangier disease due to a IVS2 +5G>C mutation in ABCA1 gene. 12576507

2003

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease
1.000 GeneticVariation LHGDN A three-decade search for a culprit in Tangier disease led to the identification of mutations in a cell membrane protein called ABCA1, which mediates the secretion of excess cholesterol from cells into the HDL metabolic pathway. 16235041

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease
1.000 GeneticVariation LHGDN Mutations in ATP-binding cassette transporter A1 (ABCA1) cause Tangier disease and familial hypoalphalipoproteinemia, resulting in low to absent plasma high-density lipoprotein cholesterol levels. 16873719

2006

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.550 AlteredExpression LHGDN Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. 15851589

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Severe Tangier disease with a novel ABCA1 gene mutation. 18955690

2008

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver. 17521614

2007