Source: CTD_mouse

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker CTD_mouse Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice. 12165863

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker CTD_mouse Ezrin Inhibition Up-regulates Stress Response Gene Expression. 27137931

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1261473
Disease: Sarcoma
Sarcoma
1.000 Biomarker CTD_mouse There was no loss of heterozygosity at the wildtype Trp53 locus in twenty-five sarcomas or four hepatocellular tumors examined. 19258306

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_mouse Thus, this study supports a model that, in the face of chronic liver damage, attenuated p53 function and telomere-induced chromosomal instability play critical and cooperative roles in the progression of hepatocellular carcinoma. 16651430

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_mouse p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse. 19919837

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0017638
Disease: Glioma
Glioma
0.900 Biomarker CTD_mouse PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. 25119042

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.900 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.900 Biomarker CTD_mouse Functions of TAp63 and p53 in restraining the development of metastatic cancer. 23873029

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker CTD_mouse Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice. 12165863

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_mouse These results provide the in vivo experimental evidence of synergistic interactions of ras and p53 in lung tumor progression. 16247444

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.800 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.800 Biomarker CTD_mouse A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. 16247444

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.800 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.800 Biomarker CTD_mouse To investigate whether simultaneous depletion of both p53 and TAp63 can recapitulate the effect of mutant p53 expression in vivo, we used a mouse model of pancreatic cancer in which the expression of mutant p53 resulted in the rapid appearance of primary tumours and metastases. 23873029

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker CTD_mouse A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. 16247444

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker CTD_mouse Overexpression of p53 protein, which is frequently demonstrated in virulent phenotypes of human corpus cancers, was seen in three out of eight (38%) adenocarcinomas, but not in the atypical hyperplasia or normal endometrial glands. 7955072

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.700 Biomarker CTD_mouse Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. 16860786

2007

Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.700 Biomarker CTD_mouse Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice. 19775285

2010

Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700 Biomarker CTD_mouse A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. 17151334

2007

Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700 Biomarker CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703

2018

Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.700 Biomarker CTD_mouse Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. 18056790

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.700 Biomarker CTD_mouse Accordingly, combined suppression of Spry4, Nf1 and p53 produces high levels of Ras signaling and drives AML in mice. 25822087

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms
0.700 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms
0.700 Biomarker CTD_mouse Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. 22009531

2011