×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
CTD_mouse
Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice.
12165863
2002
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Osteosarcoma
1.000
Biomarker
CTD_mouse
Ezrin Inhibition Up-regulates Stress Response Gene Expression.
27137931
2016
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Sarcoma
1.000
Biomarker
CTD_mouse
There was no loss of heterozygosity at the wildtype Trp53 locus in twenty-five sarcomas or four hepatocellular tumors examined.
19258306
2009
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Liver carcinoma
1.000
Biomarker
CTD_mouse
Thus, this study supports a model that, in the face of chronic liver damage, attenuated p53 function and telomere-induced chromosomal instability play critical and cooperative roles in the progression of hepatocellular carcinoma .
16651430
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Liver carcinoma
1.000
Biomarker
CTD_mouse
p53 Mutations are very common in human hepatocellular carcinoma , and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse.
19919837
2010
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Glioma
0.900
Biomarker
CTD_mouse
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.
25119042
2014
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Pancreatic Neoplasm
0.900
Biomarker
CTD_mouse
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
26390243
2015
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Pancreatic Neoplasm
0.900
Biomarker
CTD_mouse
Functions of TAp63 and p53 in restraining the development of metastatic cancer.
23873029
2014
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
CTD_mouse
Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice.
12165863
2002
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Lung Neoplasms
0.800
Biomarker
CTD_mouse
These results provide the in vivo experimental evidence of synergistic interactions of ras and p53 in lung tumor progression.
16247444
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Lung Neoplasms
0.800
Biomarker
CTD_mouse
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
26390243
2015
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Malignant neoplasm of lung
0.800
Biomarker
CTD_mouse
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
26390243
2015
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Malignant neoplasm of lung
0.800
Biomarker
CTD_mouse
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice.
16247444
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Malignant neoplasm of pancreas
0.800
Biomarker
CTD_mouse
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
26390243
2015
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Malignant neoplasm of pancreas
0.800
Biomarker
CTD_mouse
To investigate whether simultaneous depletion of both p53 and TAp63 can recapitulate the effect of mutant p53 expression in vivo, we used a mouse model of pancreatic cancer in which the expression of mutant p53 resulted in the rapid appearance of primary tumours and metastases.
23873029
2014
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Adenocarcinoma
0.700
Biomarker
CTD_mouse
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice.
16247444
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Adenocarcinoma
0.700
Biomarker
CTD_mouse
Overexpression of p53 protein, which is frequently demonstrated in virulent phenotypes of human corpus cancers, was seen in three out of eight (38%) adenocarcinomas , but not in the atypical hyperplasia or normal endometrial glands.
7955072
1994
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Brain Neoplasms
0.700
Biomarker
CTD_mouse
Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.
16860786
2007
×
Entrez Id:
3630
Gene Symbol:
INS
INS
Diabetes Mellitus
0.700
Biomarker
CTD_mouse
Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice.
19775285
2010
×
Entrez Id:
3630
Gene Symbol:
INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
CTD_mouse
A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
17151334
2007
×
Entrez Id:
3630
Gene Symbol:
INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
CTD_mouse
Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice.
29420703
2018
×
Entrez Id:
3630
Gene Symbol:
INS
INS
Hyperglycemia
0.700
Biomarker
CTD_mouse
Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
18056790
2008
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Leukemia, Myelocytic, Acute
0.700
Biomarker
CTD_mouse
Accordingly, combined suppression of Spry4, Nf1 and p53 produces high levels of Ras signaling and drives AML in mice.
25822087
2015
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Skin Neoplasms
0.700
Biomarker
CTD_mouse
Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.
27923803
2017
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Skin Neoplasms
0.700
Biomarker
CTD_mouse
Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.
22009531
2011