Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Cancer
0.390 Biomarker CLINGEN To determine a possible role of MSH3 as predisposing to CRC in Lynch syndrome, we screened MSH3 for germ-line mutations in 79 unrelated Lynch patients who were negative for pathogenetic mutations in MLH1, MSH2 and MSH6. 21128252

2011

Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Cancer
0.390 Biomarker CLINGEN hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. 8942985

1996

Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Cancer
0.390 Biomarker CLINGEN hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. 8805365

1996

Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Cancer
0.390 Biomarker CLINGEN The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. 10706084

2000

Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Cancer
0.390 Biomarker CLINGEN Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. 23228367

2013

Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Cancer
0.390 Biomarker CLINGEN Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. 27476653

2016