Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.220 Biomarker MGD

Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. 19284971

2009
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. 18787106

2008
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. 19700744

2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. 1436033

1992
Entrez Id: 3399
Gene Symbol: ID3
ID3
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. 15485632

2004
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. 1416659

1992
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD T-cell receptor repertoire of infiltrating T cells in lachrymal glands, salivary glands and kidneys from alymphoplasia (aly) mutant mice: a new model for Sjögren's syndrome. 9010048

1996
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. 762500

1979
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. 14764671

2004
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene. 10875266

2000
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. 16473829

2006
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Homeostatic regulation of intestinal villous epithelia by B lymphocytes. 11884426

2002
Entrez Id: 4792
Gene Symbol: NFKBIA
NFKBIA
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. 20696914

2010
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance. 16709807

2006
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice. 17207605

2006
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. 22590468

2012
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. 9826549

1998
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Type I IFN protects against murine lupus. 15265950

2004
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. 3009614

1986
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Another cell death induction system: TNF-alpha acts as a ligand for Fas in vaginal cells. 10453074

1999
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. 12486097

2002
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice. 6444324

1980
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. 9618522

1998
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. 11567045

2001