Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 326
Gene Symbol: AIRE
AIRE
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. 15699112

2005
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. 16473829

2006
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. 22538615

2012
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD CCR7 signals are essential for cortex-medulla migration of developing thymocytes. 15302902

2004
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene. 10875266

2000
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. 9826549

1998
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. 9618522

1998
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome. 15314222

2004
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages. 25447050

2015
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene. 10393934

1999
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. 11356695

2001
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Aromatase-deficient (ArKO) mice have reduced blood pressure and baroreflex sensitivity. 15178650

2004
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD E2f1 mutation induces early onset of diabetes and Sjögren's syndrome in nonobese diabetic mice. 15470032

2004
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD MRL/MP-lpr/lpr mouse as a model of immune-induced sensorineural hearing loss. 1416659

1992
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. 762500

1979
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Type I IFN protects against murine lupus. 15265950

2004
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. 3009614

1986
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Another cell death induction system: TNF-alpha acts as a ligand for Fas in vaginal cells. 10453074

1999
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. 12486097

2002
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice. 6444324

1980
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. 11567045

2001
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. 12974753

2003
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Transfer of Sjögren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. 7957574

1994
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. 309911

1978
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjögren's syndrome. 8163351

1994