Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.240 Biomarker RGD Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. 8441230

1993

Entrez Id: 3990
Gene Symbol: LIPC
LIPC
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone. 8636395

1996

Entrez Id: 9365
Gene Symbol: KL
KL
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Biomarker RGD This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure. 9731228

1998

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Biomarker RGD Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate. 10919844

2000

Entrez Id: 23560
Gene Symbol: GTPBP4
GTPBP4
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. 11316846

2001

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.290 Biomarker RGD Expression of monocyte chemoattractant protein-1 in proximal tubular epithelial cells in a rat model of progressive kidney failure. 12080327

2002

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. 12110012

2002

Entrez Id: 8435
Gene Symbol: SOAT2
SOAT2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure. 12217884

2002

Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Downregulation of intestinal cytochrome p450 in chronic renal failure. 12039987

2002

Entrez Id: 729
Gene Symbol: C6
C6
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 ModifyingMutation RGD C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. 11912252

2002

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Therapeutic RGD Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet. 14586729

2003

Entrez Id: 4973
Gene Symbol: OLR1
OLR1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD These results suggest that enhanced renal expression of LOX-1 might play some roles in the progression of chronic renal failure in rats. 12661921

2003

Entrez Id: 3931
Gene Symbol: LCAT
LCAT
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.220 Biomarker RGD ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure. 15280162

2004

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD [Curative machanism of Shenle capsule on 5/6 nephrectomy rats]. 15506291

2004

Entrez Id: 6569
Gene Symbol: SLC34A1
SLC34A1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Regulation of NaPi-IIa mRNA and transporter protein in chronic renal failure: role of parathyroid hormone (PTH) and dietary phosphate (Pi). 15452708

2004

Entrez Id: 23175
Gene Symbol: LPIN1
LPIN1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. 14718385

2004

Entrez Id: 4036
Gene Symbol: LRP2
LRP2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Modulation of gene expression by moxonidine in rats with chronic renal failure. 15266031

2004

Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Iron and oxidative stress in renal insufficiency. 15550752

2005

Entrez Id: 384
Gene Symbol: ARG2
ARG2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. 16809898

2006

Entrez Id: 5228
Gene Symbol: PGF
PGF
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Microvasculature change and placenta growth factor expression in the early stage of a rat remnant kidney model. 16543713

2006

Entrez Id: 5734
Gene Symbol: PTGER4
PTGER4
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Therapeutic RGD Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure. 16871242

2006

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Biomarker RGD Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. 17200156

2007

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Down-regulation of intestinal drug transporters in chronic renal failure in rats. 17135344

2007

Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Role of dietary phosphorus and degree of uremia in the development of renal bone disease in rats. 17365904

2007

Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of intestinal drug transporters in chronic renal failure in rats. 17135344

2007