Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8777
Gene Symbol: MPDZ
MPDZ
CUI: C0149821
Disease: ACUTE ALCOHOL WITHDRAWAL
ACUTE ALCOHOL WITHDRAWAL
0.310 Biomarker PSYGENET Exploratory haplotype and single SNP association analyses suggest a possible association between the MPDZ gene and alcohol dependence but not AWS. 19175764

2009

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0149821
Disease: ACUTE ALCOHOL WITHDRAWAL
ACUTE ALCOHOL WITHDRAWAL
0.300 Biomarker PSYGENET During acute alcohol withdrawal, both male LAP lines, and LAP1 females, showed reduced startle responses at the 4-hour time point during acute alcohol withdrawal. 17850641

2007

Entrez Id: 1974
Gene Symbol: EIF4A2
EIF4A2
CUI: C0394996
Disease: Acute alcoholic intoxication
Acute alcoholic intoxication
0.300 Biomarker PSYGENET Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F. 11052957

2000

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0857501
Disease: Acute schizophrenia
Acute schizophrenia
0.320 Biomarker PSYGENET These results suggest that IFNG and proteins affected by IFNG may play a role in the pathogenesis of schizophrenia. 22623148

2012

Entrez Id: 1152
Gene Symbol: CKB
CKB
CUI: C0857501
Disease: Acute schizophrenia
Acute schizophrenia
0.300 Biomarker PSYGENET When we analyzed the genetic polymorphisms of the single nucleotide polymorphisms (SNPs) of their human orthologous genes in a Korean population, the promoter SNPs of CKB and TPI1 were weakly associated with schizophrenia. 22623148

2012

Entrez Id: 7167
Gene Symbol: TPI1
TPI1
CUI: C0857501
Disease: Acute schizophrenia
Acute schizophrenia
0.300 Biomarker PSYGENET When we analyzed the genetic polymorphisms of the single nucleotide polymorphisms (SNPs) of their human orthologous genes in a Korean population, the promoter SNPs of CKB and TPI1 were weakly associated with schizophrenia. 22623148

2012

Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0858355
Disease: Addicted to cocaine
Addicted to cocaine
0.310 Biomarker PSYGENET We also detected a biased PER2 genotype distribution among healthy controls and cocaine-addicted individuals. 22832851

2013

Entrez Id: 2912
Gene Symbol: GRM2
GRM2
CUI: C0858355
Disease: Addicted to cocaine
Addicted to cocaine
0.300 Biomarker PSYGENET In an attempt to dissect the role played by mGluR2 and mGluR3 in cue-induced reinstatement, we analyzed the mRNA expression patterns in several relevant brain areas but did not find any significant differences between cocaine addict-like and non-addict-like rats, suggesting that the behavioral differences observed are due to translational rather than transcriptional regulation. 23624743

2014

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0858355
Disease: Addicted to cocaine
Addicted to cocaine
0.300 Biomarker PSYGENET In an attempt to dissect the role played by mGluR2 and mGluR3 in cue-induced reinstatement, we analyzed the mRNA expression patterns in several relevant brain areas but did not find any significant differences between cocaine addict-like and non-addict-like rats, suggesting that the behavioral differences observed are due to translational rather than transcriptional regulation. 23624743

2014

Entrez Id: 79971
Gene Symbol: WLS
WLS
CUI: C0858355
Disease: Addicted to cocaine
Addicted to cocaine
0.010 Biomarker PSYGENET In this study, we conducted a case-control association analysis of 16 WLS genetic variants in opioid and cocaine addicted individuals of both African-American (opioid n=336, cocaine n=908) and European-American (opioid n=335, cocaine n=336) ancestry. 23566366

2014

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.350 Biomarker PSYGENET Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis. 18092319

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.350 Biomarker PSYGENET In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis. 18407467

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.350 Biomarker PSYGENET Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis. 20591499

2011

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.350 Biomarker PSYGENET Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications. 20493536

2010

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.350 Biomarker PSYGENET Our findings suggest that genetic variations of COMT can contribute to the enlargement of the lateral ventricles described in early phases of non-affective psychosis. 17706335

2007

Entrez Id: 267012
Gene Symbol: DAOA
DAOA
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.320 Biomarker PSYGENET Polymorphisms in the G72 (also named d-amino acid oxidase activator, DAOA) gene increase the vulnerability for schizophrenia and affective psychosis. 20005295

2011

Entrez Id: 267012
Gene Symbol: DAOA
DAOA
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.320 Biomarker PSYGENET Our data revealed potential evidence for partially overlapping risk haplotypes at the DAOA/G30 locus in Leonhard's affective psychoses, but do not support a common genetic contribution of the DAOA/G30 gene complex to the pathogenesis of affective disorders. 20667145

2010

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.310 Biomarker PSYGENET Two polymorphisms in the 5-HTT gene (a 44 bp insertion/deletion in the promoter region and the functional polymorphism rs25531) were genotyped in a sample of 147 drug-naïve patients experiencing a first episode of a non-affective psychosis. 20031235

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.310 Biomarker PSYGENET To further explore the connection between homocysteinemia and affective psychoses, a case-control study examining the C677T and the A1298C variants of methylenetetrahydrofolate reductase was conducted. 16055253

2006

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.310 Biomarker PSYGENET We report here studies of the effects of the 5-HTTLPR polymorphism on the probability that an individual will develop mental maladaptation in 224 close relatives of patients with severe chronic mental disorders - schizophrenia and schizoaffective and affective psychoses. 18264772

2008

Entrez Id: 3240
Gene Symbol: HP
HP
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.300 Biomarker PSYGENET Affective psychoses are characterized by an excess of the haptoglobin (Hp) serum type 2-2 (p less than 0.001). 6182580

1982

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0001723
Disease: Affective Disorders, Psychotic
Affective Disorders, Psychotic
0.010 Biomarker PSYGENET Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis. 18180150

2008

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.710 Biomarker PSYGENET Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders. 12967770

2003

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.710 Biomarker PSYGENET The role of DRD2 and NPY on alcohol dependence was also supported. 20554694

2010

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.590 Biomarker PSYGENET The ALDH2*2 allele, detected in nearly half of the subjects, showed an overwhelming protective effect against a high level of alcohol consumption and problem drinking behavior, as determined by the Kurihama Alcoholism Screening Test (KAST). 12211622

2002