Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Protein abnormalities in adult respiratory distress syndrome, tuberculosis, and cystic fibrosis sera. 2432615

1987

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET In the present study we tested two polymorphisms in the alpha-2 macroglobulin gene, a 5 bp deletion at the 5' splice site of exon 18 and a G/A point mutation (V1000I) in exon 24, in a sample of 118 healthy, non demented controls and 238 consecutively recruited gerontopsychiatric patients, diagnosed as: Alzheimer's disease (N=88), mild cognitive impairment (N=32), subjective cognitive complaints (N=54) and depression/other psychiatric disorders (N=64). 11058789

2000

Entrez Id: 15
Gene Symbol: AANAT
AANAT
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET The mutant, AANAT knocked down C57BL/6J mice displayed significantly longer times of immobility ("depression"). 11316327

2001

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET The present study suggests that the C3435T polymorphism of the MDR1 gene affects the formation of a depression-prone personality trait in Japanese females. 24577069

2014

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Silencing clusterin gene transcription on effects of multidrug resistance reversing of human hepatoma HepG2/ADM cells. 25600802

2015

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Our findings suggest that single nucleotide polymorphisms in the ABCB1 gene may be indicators of the severity of depression and of the likely S-CIT treatment remission response in MDD. 20859246

2011

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Impact of ABCB1 variants on neutrophil depression: a pharmacogenomic study of paclitaxel in 92 women with ovarian cancer. 21955855

2012

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Results suggest that antidepressant treatment of depression can be optimized by the clinical application of ABCB1 genotyping. 23880209

2014

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Previous studies have revealed the association of the ACE gene insertion/deletion polymorphism with depressive disorder and its treatment response but not with the depressive symptoms in schizophrenia. 25694211

2015

Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET Aberrant REST-mediated transcriptional regulation in major depressive disorder. 19846118

2010

Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET Polymorphisms in ADCY8 and ADCY5 and within a lincRNA are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. 23278386

2013

Entrez Id: 113
Gene Symbol: ADCY7
ADCY7
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.330 Biomarker PSYGENET Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness. 17135423

2006

Entrez Id: 113
Gene Symbol: ADCY7
ADCY7
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.330 Biomarker PSYGENET This converging cross-species evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression, together supporting a continuous dimensional approach to major depressive disorder and other affective disorders. 22264442

2012

Entrez Id: 114
Gene Symbol: ADCY8
ADCY8
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Polymorphisms in ADCY8 and ADCY5 and within a lincRNA are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. 23278386

2013

Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Adult PACAP(-/-) mice showed not only hyperactivity, jumping behavior, and depression-like behavior, but also decreased social interaction. 20144662

2010

Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. 19914336

2010

Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger-Westphal nucleus, ventral lateral septum, and dorsal raphe nucleus. 22178610

2012

Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET We previously found that juvenile pituitary adenylate cyclase-activating polypeptide (PACAP)-knockout (PACAP(-/-)) mice reared in an enriched environment (EE) for 4 weeks showed attenuated hyperactivity, jumping behavior, impairments in social interaction, and depression-like behavior. 25014004

2014

Entrez Id: 150
Gene Symbol: ADRA2A
ADRA2A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.330 Biomarker PSYGENET The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. 16333651

2006

Entrez Id: 150
Gene Symbol: ADRA2A
ADRA2A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.330 Biomarker PSYGENET Our findings suggest that ADRA2A plays an important role in depression therapy. 18794646

2008

Entrez Id: 150
Gene Symbol: ADRA2A
ADRA2A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.330 Biomarker PSYGENET The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo. 21859713

2011

Entrez Id: 150
Gene Symbol: ADRA2A
ADRA2A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.330 Biomarker PSYGENET The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. 11425914

2001

Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET This study tested for an association between SLC18A2 and ADRB1 and treatment outcome in 873 major depressive disorder patients treated with the antidepressant citalopram in the Sequenced Treatment Alternatives to Relieve Depression study. 18797399

2008

Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET let-7e replacement yields potent anti-arrhythmic efficacy via targeting beta 1-adrenergic receptor in rat heart. 24758696

2014

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.330 Biomarker PSYGENET Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen. 24016839

2013