Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. 16495393

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. 16495393

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer. 18086299

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer. 18086299

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. 25221644

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. 25221644

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. 16091755

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. 16091755

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Combining the anti-HER2 antibody trastuzumab with taxanes in breast cancer: results and trial considerations. 11970740

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Combining the anti-HER2 antibody trastuzumab with taxanes in breast cancer: results and trial considerations. 11970740

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Comparison of HER2 status by fluorescence in situ hybridization and immunohistochemistry to predict benefit from dose escalation of adjuvant doxorubicin-based therapy in node-positive breast cancer patients. 15994142

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Comparison of HER2 status by fluorescence in situ hybridization and immunohistochemistry to predict benefit from dose escalation of adjuvant doxorubicin-based therapy in node-positive breast cancer patients. 15994142

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma. 12655533

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma. 12655533

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. 21501481

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. 21501481

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. 20197467

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. 20197467

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. 20332317

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. 20332317

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Efficacy of high-dose alkylating chemotherapy in HER2/neu-negative breast cancer. 16446318

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Efficacy of high-dose alkylating chemotherapy in HER2/neu-negative breast cancer. 16446318

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer. 12839951

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer. 12839951

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Evaluation of the HER2/neu-derived peptide GP2 for use in a peptide-based breast cancer vaccine trial. 16596621

2006