Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.800 Biomarker PSYGENET We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P < 0.05) in Caucasian subjects, but not African-American individuals. 24078558

2013

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.800 Biomarker PSYGENET We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554

2010

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.800 Biomarker PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583

2010

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.800 Biomarker PSYGENET Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. 22832851

2012

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.800 Biomarker PSYGENET Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram. 23635803

2013

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554

2010

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively. 19462300

2009

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583

2010

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD. 20170711

2010

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. 21150910

2011

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. 12218660

2002

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Although platelet 5-HTT densities are reduced in patients with cocaine dependence compared with healthy volunteers, these genotypic variations in the serotonin transporter do not seem to influence levels of platelet 5-HTT in cocaine-dependent patients or healthy volunteers. 15091312

2004

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET We genotyped the SLC6A4 5-HTTLPR (rs4795541, rs25531) and TPH2 1125A>T (rs4290270) variants and evaluated their role in moderating disulfiram treatment for cocaine dependence. 22925276

2012

Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324

2010

Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction. 20133874

2010

Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. 22882391

2013

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence. 11092766

2000

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. 22882391

2013

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Studies of polymorphisms in the mu opioid receptor gene, which encodes the receptor target of some endogenous opioids, heroin, morphine, and synthetic opioids, have contributed substantially to knowledge of genetic influences on opiate and cocaine addiction. 15734726

2005

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). 17622222

2008

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583

1996

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Here, we examined whether the OPRK1 rs6989250 C>G affects stress-induced cocaine craving and cortisol responses, subsequent cocaine relapse risk and the neural response to stress using functional magnetic resonance imaging (fMRI) in cocaine dependence. 23962922

2013

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET This study indicates that a patient's OPRK1 genotype could be used to identify a subset of individuals for whom vaccine treatment may be an effective pharmacotherapy for cocaine dependence. 23995774

2013

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Evidence suggests that the kappa-opioid receptor (KOP-r) system plays an important role in cocaine addiction. 17532787

2007

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET We investigated the relationship of a polymorphism in the 5' promoter region of the serotonin transporter gene (5-HTTLPR) with prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP) in a sample of 68 African-American individuals, 35 CD subjects and 33 controls. 17000009

2006