Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583

2011

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET A patient's genotype for ANKK1, DRD2, or both, may be used to identify individuals for whom disulfiram may be an effective pharmacotherapy for cocaine dependence. 23635803

2014

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P?<?0.05) in Caucasian subjects, but not African-American individuals. 24078558

2014

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. 22832851

2013

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine ?-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554

2011

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.560 Biomarker PSYGENET Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD. 20170711

2010

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.560 Biomarker PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583

2011

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.560 Biomarker PSYGENET We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine ?-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554

2011

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.560 Biomarker PSYGENET Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. 21150910

2011

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.560 Biomarker PSYGENET Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively. 19462300

2009

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET These results suggest that dynorphin in a very specific area of the nucleus accumbens contributes to depressive-like states and may be involved in neuroadaptations in the NAcc that contribute to the development of cocaine addiction as a persistent and lasting condition. 24816773

2015

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET In this study, 3 polymorphisms in PDYN (rs1022563, rs910080 and rs1997794) were genotyped in opioid-addicted [248 African Americans (AAs) and 1040 European Americans (EAs)], cocaine-addicted (1248 AAs and 336 EAs) and control individuals (674 AAs and 656 EAs). 22443215

2012

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET This study provides evidence that a 3'UTR PDYN haplotype, implicated in vulnerability to develop cocaine addiction and/or cocaine/alcohol codependence, is related to lower mRNA expression of the PDYN gene in human dorsal and ventral striatum. 18923396

2009

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Our results suggest that this allelic variation at the promoter region of the prodynorphin gene (alleles with three or four repeats), which may result in enhanced transcription of the gene, may contribute to relative protection and decrease individual vulnerability to develop cocaine dependence or abuse. 11992566

2002

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. 16184603

2006

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Here, we examined whether the OPRK1 rs6989250 C>G affects stress-induced cocaine craving and cortisol responses, subsequent cocaine relapse risk and the neural response to stress using functional magnetic resonance imaging (fMRI) in cocaine dependence. 23962922

2014

Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction. 20133874

2010

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Although platelet 5-HTT densities are reduced in patients with cocaine dependence compared with healthy volunteers, these genotypic variations in the serotonin transporter do not seem to influence levels of platelet 5-HTT in cocaine-dependent patients or healthy volunteers. 15091312

2004

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence. 11092766

2001

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). 17622222

2008

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET We genotyped the SLC6A4 5-HTTLPR (rs4795541, rs25531) and TPH2 1125A>T (rs4290270) variants and evaluated their role in moderating disulfiram treatment for cocaine dependence. 22925276

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET We investigated the relationship of a polymorphism in the 5' promoter region of the serotonin transporter gene (5-HTTLPR) with prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP) in a sample of 68 African-American individuals, 35 CD subjects and 33 controls. 17000009

2007

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Evidence suggests that the kappa-opioid receptor (KOP-r) system plays an important role in cocaine addiction. 17532787

2007

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. 12218660

2003

Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324

2010