Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583

1997

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822

1999

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence. 11092766

2001

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction. 11268215

2001

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Our results suggest that this allelic variation at the promoter region of the prodynorphin gene (alleles with three or four repeats), which may result in enhanced transcription of the gene, may contribute to relative protection and decrease individual vulnerability to develop cocaine dependence or abuse. 11992566

2002

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. 12218660

2003

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET These interesting preclinical findings with BP 897 provide additional validation for dopamine D(3) receptor as a therapeutic target for the treatment of cocaine abuse and its associated central nervous system (CNS) disorders. 12847556

2003

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Although platelet 5-HTT densities are reduced in patients with cocaine dependence compared with healthy volunteers, these genotypic variations in the serotonin transporter do not seem to influence levels of platelet 5-HTT in cocaine-dependent patients or healthy volunteers. 15091312

2004

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Studies of polymorphisms in the mu opioid receptor gene, which encodes the receptor target of some endogenous opioids, heroin, morphine, and synthetic opioids, have contributed substantially to knowledge of genetic influences on opiate and cocaine addiction. 15734726

2005

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET Our data do not support a role for the dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample. 16094250

2005

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET These results support the idea that Cdk5 activity is involved in altered gene expression after chronic exposure to cocaine and hence impacts the long-lasting changes in neuronal function underlying cocaine addiction. 15665076

2005

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Modulation of cocaine reward is a novel action of the melanocortin-MC4-R system and could be targeted for the development of new medications for cocaine addiction. 15869520

2005

Entrez Id: 50632
Gene Symbol: CALY
CALY
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET These results suggest that these two genetic variants in the CALCYON gene do not play a major role in predisposition to either schizophrenia or cocaine dependence in AA or EA subjects. 14755439

2005

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. 16184603

2006

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. 16314880

2006

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects. 16759340

2006

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. 16272961

2006

Entrez Id: 5074
Gene Symbol: PAWR
PAWR
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET The results of this study suggest that variations in the human Par-4 gene are unlikely to play a major role in the pathophysiology of cocaine dependence. 16969273

2006

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET We investigated the relationship of a polymorphism in the 5' promoter region of the serotonin transporter gene (5-HTTLPR) with prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP) in a sample of 68 African-American individuals, 35 CD subjects and 33 controls. 17000009

2007

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Evidence suggests that the kappa-opioid receptor (KOP-r) system plays an important role in cocaine addiction. 17532787

2007

Entrez Id: 3351
Gene Symbol: HTR1B
HTR1B
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.500 Biomarker PSYGENET Thus, 5-HT(1B) mRNA is upregulated by repeated exposure to cocaine and perhaps by social stress as well; both of these factors are relevant to the risk for relapse in cocaine addiction. 17059838

2007

Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. 17106427

2007

Entrez Id: 5187
Gene Symbol: PER1
PER1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. 17106427

2007

Entrez Id: 157
Gene Symbol: GRK3
GRK3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET In conclusion, our results do not support a major role for GRK3 gene promoter variants in cocaine addiction. 17621168

2007

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). 17622222

2008