Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6079
Gene Symbol: SNORD15A
SNORD15A
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET To further address the role of snoRNA in cocaine addiction, we show that repeated exposure and conditioned place preference (CPP) training to cocaine negatively regulates the expression of MBII-52 mRNA level, which is a brain-specific C/D box snoRNA, but not influences the serotonin receptor 2C (5HT2CR) mRNA level in NAc. 24979384

2014

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET To investigate the possible contribution of rare variants to the development of substance dependencies other than nicotine dependence, specifically alcohol and cocaine dependence, we undertook pooled sequencing of the coding regions and flanking sequence of CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 in 287 African American and 1028 European American individuals from the Collaborative Study of the Genetics of Alcoholism (COGA). 24057674

2014

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our studies indicate that the AVP and its V1b receptor system may be a potential therapeutic target for treating anxiety and depressive symptoms associated with cocaine addiction. 21677651

2011

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our findings propose a new role for AVP in cocaine addiction. 19596360

2010

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Modulation of cocaine reward is a novel action of the melanocortin-MC4-R system and could be targeted for the development of new medications for cocaine addiction. 15869520

2005

Entrez Id: 2587
Gene Symbol: GALR1
GALR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. 24766650

2014

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Variants in the CLOCK gene were significantly associated with the heavy cocaine use, infrequent intravenous injection group, but not with the DSM-IV diagnosis of CD. 24339190

2014

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET For African Americans, we find decreased cocaine dependence symptoms among carriers of missense variants in CHRNA3 (FamSKAT P = 0.005). 24057674

2014

Entrez Id: 255239
Gene Symbol: ANKK1
ANKK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram. 23635803

2013

Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET This study indicates that a patient's ADRA1A genotype could be used to identify a subset of individuals for which disulfiram and, perhaps, other α1-adrenoceptor blockers may be an effective pharmacotherapy for cocaine dependence. 23849431

2013

Entrez Id: 23413
Gene Symbol: NCS1
NCS1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent. 22999924

2012

Entrez Id: 4128
Gene Symbol: MAOA
MAOA
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET The impact of cocaine addiction on GMV, tested by (1) comparing the CUD group with controls, (2) testing diagnosis × MAOA interactions, and (3) correlating GMV with lifetime cocaine, alcohol, and cigarette smoking, and testing their unique contribution to GMV beyond other factors. 21383264

2011

Entrez Id: 6571
Gene Symbol: SLC18A2
SLC18A2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Bakuchiol analogs, especially Delta3,2-hydroxybakuchiol, are monoamine transporter inhibitors involved in regulating dopaminergic and noradrenergic neurotransmission and may have represented potential pharmacotherapies for disorders such as Parkinson's disease, depression, and cocaine addiction. 18329002

2008

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET These results support the idea that Cdk5 activity is involved in altered gene expression after chronic exposure to cocaine and hence impacts the long-lasting changes in neuronal function underlying cocaine addiction. 15665076

2005

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. 16272961

2005

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction. 11268215

2001

Entrez Id: 1142
Gene Symbol: CHRNB3
CHRNB3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET For European Americans, we find increased DSM-IV cocaine dependence symptoms (FamSKAT P = 2 × 10(-4)) and increased DSM-IV alcohol dependence symptoms (FamSKAT P = 5 × 10(-4)) among carriers of missense variants in CHRNB3. 24057674

2014

Entrez Id: 4905
Gene Symbol: NSF
NSF
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET Our data show preliminary evidence that NSF may predispose not only to cocaine dependence, but also to an early onset of the dependence. 21426264

2012

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET We genotyped the SLC6A4 5-HTTLPR (rs4795541, rs25531) and TPH2 1125A>T (rs4290270) variants and evaluated their role in moderating disulfiram treatment for cocaine dependence. 22925276

2012

Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET Taken together, these results provide preliminary evidence for the role of the PER2 gene in regulating striatal D2R availability in the human brain and in vulnerability for cocaine addiction. 22832851

2012

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects. 16759340

2006

Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. 17106427

2006

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET To investigate the possible contribution of rare variants to the development of substance dependencies other than nicotine dependence, specifically alcohol and cocaine dependence, we undertook pooled sequencing of the coding regions and flanking sequence of CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 in 287 African American and 1028 European American individuals from the Collaborative Study of the Genetics of Alcoholism (COGA). 24057674

2014