Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 409
Gene Symbol: ARRB2
ARRB2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET Association study of the ?-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. 22472784

2012

Entrez Id: 441549
Gene Symbol: CDNF
CDNF
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET Our study suggests that there is no association between variants in the CDNF gene and cocaine dependence. 19429035

2009

Entrez Id: 5187
Gene Symbol: PER1
PER1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. 17106427

2007

Entrez Id: 157
Gene Symbol: GRK3
GRK3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET In conclusion, our results do not support a major role for GRK3 gene promoter variants in cocaine addiction. 17621168

2007

Entrez Id: 5074
Gene Symbol: PAWR
PAWR
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET The results of this study suggest that variations in the human Par-4 gene are unlikely to play a major role in the pathophysiology of cocaine dependence. 16969273

2006

Entrez Id: 50632
Gene Symbol: CALY
CALY
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.010 Biomarker PSYGENET These results suggest that these two genetic variants in the CALCYON gene do not play a major role in predisposition to either schizophrenia or cocaine dependence in AA or EA subjects. 14755439

2005

Entrez Id: 6079
Gene Symbol: SNORD15A
SNORD15A
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET To further address the role of snoRNA in cocaine addiction, we show that repeated exposure and conditioned place preference (CPP) training to cocaine negatively regulates the expression of MBII-52 mRNA level, which is a brain-specific C/D box snoRNA, but not influences the serotonin receptor 2C (5HT2CR) mRNA level in NAc. 24979384

2015

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET To investigate the possible contribution of rare variants to the development of substance dependencies other than nicotine dependence, specifically alcohol and cocaine dependence, we undertook pooled sequencing of the coding regions and flanking sequence of CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 in 287 African American and 1028 European American individuals from the Collaborative Study of the Genetics of Alcoholism (COGA). 24057674

2014

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our studies indicate that the AVP and its V1b receptor system may be a potential therapeutic target for treating anxiety and depressive symptoms associated with cocaine addiction. 21677651

2012

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our findings propose a new role for AVP in cocaine addiction. 19596360

2010

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET These results support the idea that Cdk5 activity is involved in altered gene expression after chronic exposure to cocaine and hence impacts the long-lasting changes in neuronal function underlying cocaine addiction. 15665076

2005

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Modulation of cocaine reward is a novel action of the melanocortin-MC4-R system and could be targeted for the development of new medications for cocaine addiction. 15869520

2005

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction. 11268215

2001

Entrez Id: 2587
Gene Symbol: GALR1
GALR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. 24766650

2015

Entrez Id: 255239
Gene Symbol: ANKK1
ANKK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET A patient's genotype for ANKK1, DRD2, or both, may be used to identify individuals for whom disulfiram may be an effective pharmacotherapy for cocaine dependence. 23635803

2014

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET These are the first results to implicate rare variants in CHRNB3 or CHRNA3 in risk for alcohol dependence or cocaine dependence. 24057674

2014

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Variants in the CLOCK gene were significantly associated with the heavy cocaine use, infrequent intravenous injection group, but not with the DSM-IV diagnosis of CD. 24339190

2014

Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET This study indicates that a patient's ADRA1A genotype could be used to identify a subset of individuals for which disulfiram and, perhaps, other ?1-adrenoceptor blockers may be an effective pharmacotherapy for cocaine dependence. 23849431

2014

Entrez Id: 23413
Gene Symbol: NCS1
NCS1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent. 22999924

2013

Entrez Id: 4905
Gene Symbol: NSF
NSF
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Our data show preliminary evidence that NSF may predispose not only to cocaine dependence, but also to an early onset of the dependence. 21426264

2012

Entrez Id: 4128
Gene Symbol: MAOA
MAOA
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET (2) The orbitofrontal cortex reductions were uniquely driven by CUD with low- MAOA genotype and by lifetime cocaine use. 21383264

2011

Entrez Id: 6571
Gene Symbol: SLC18A2
SLC18A2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Bakuchiol analogs, especially Delta3,2-hydroxybakuchiol, are monoamine transporter inhibitors involved in regulating dopaminergic and noradrenergic neurotransmission and may have represented potential pharmacotherapies for disorders such as Parkinson's disease, depression, and cocaine addiction. 18329002

2008

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. 16272961

2006