Source: CTD_mouse

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.700 Biomarker CTD_mouse Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice. 12165863

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.700 Biomarker CTD_mouse Overexpression of p53 protein, which is frequently demonstrated in virulent phenotypes of human corpus cancers, was seen in three out of eight (38%) adenocarcinomas, but not in the atypical hyperplasia or normal endometrial glands. 7955072

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma
0.600 Biomarker CTD_mouse Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. 29438700

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.600 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker CTD_mouse Ezrin Inhibition Up-regulates Stress Response Gene Expression. 27137931

2016

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker CTD_mouse Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker CTD_mouse Functional kinomics identifies candidate therapeutic targets in head and neck cancer. 25125259

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker CTD_mouse However, simultaneous depletion of p53 and TAp63 led to both rapid tumour development and metastatic potential, although the incidence of metastases remained lower than that seen in mutant p53-expressing tumours. 23873029

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.600 Biomarker CTD_mouse PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. 25119042

2014

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.600 Biomarker CTD_mouse Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770

2014

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker CTD_mouse Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.600 Biomarker CTD_mouse Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. 22009531

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker CTD_mouse Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. 22009531

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker CTD_mouse Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. 19435901

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker CTD_mouse Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. 19435901

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0018923
Disease: Hemangiosarcoma
Hemangiosarcoma
0.600 Biomarker CTD_mouse Final report on carcinogens background document for riddelliine. 20737008

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_mouse To clearly establish a role for GSTP in lung tumorigenesis, we investigated whether deletion of the murine Gstp genes (Gstp1 and Gstp2) alters susceptibility to chemically induced lung tumors following exposure to BaP, 3-methylcholanthrene (3-MC), and urethane. 17909032

2007

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker CTD_mouse Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane. 17909032

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker CTD_mouse Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. 16543248

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.600 Biomarker CTD_mouse Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. 16818635

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker CTD_mouse Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. 16543248

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0345905
Disease: Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma
0.600 Biomarker CTD_mouse Intrahepatic cholangiocarcinoma (CCA) is a lethal malignancy of the biliary epithelium associated with p53 mutations, bile duct injury, inflammation, and fibrosis. 16818635

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of urinary bladder
0.600 Biomarker CTD_mouse High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine. 12706858

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.600 Biomarker CTD_mouse The results show that p53 (+/-) mice were sensitive to DBN treatment with respect to esophageal and bladder tumor development, with a mechanism that could be confined to early mutations of the residual p53 allele and increased cellular proliferation in the target organs. 12706858

2003