Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Type I IFN protects against murine lupus. 15265950

2004
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome. 15314222

2004
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Aromatase-deficient (ArKO) mice have reduced blood pressure and baroreflex sensitivity. 15178650

2004
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD CCR7 signals are essential for cortex-medulla migration of developing thymocytes. 15302902

2004
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD E2f1 mutation induces early onset of diabetes and Sjögren's syndrome in nonobese diabetic mice. 15470032

2004
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. 12974753

2003
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. 12810685

2003
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Homeostatic regulation of intestinal villous epithelia by B lymphocytes. 11884426

2002
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. 12486097

2002
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. 12196288

2002
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. 11567045

2001
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. 11356695

2001
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene. 10875266

2000
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Mammary glands of Aly mice: developmental changes and lactation-related expression of specific proteins, alpha-casein, GLyCAM-1 and MAdCAM-1. 10910194

2000
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 11067882

2000
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Another cell death induction system: TNF-alpha acts as a ligand for Fas in vaginal cells. 10453074

1999
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene. 10393934

1999
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. 9826549

1998
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. 9618522

1998
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD aly/aly mice: a unique model of biliary disease. 9620319

1998
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD T-cell receptor repertoire of infiltrating T cells in lachrymal glands, salivary glands and kidneys from alymphoplasia (aly) mutant mice: a new model for Sjögren's syndrome. 9010048

1996
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Reduced cell-cell communication in a spontaneous murine model of autoimmune thyroid disease. 7628400

1995
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Transfer of Sjögren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. 7957574

1994
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjögren's syndrome. 8163351

1994
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Cognitive and neurologic deficits in the MRL/lpr mouse: a clinicopathologic study. 8496852

1993