Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 Biomarker PSYGENET Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders. 12967770

2003

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.720 Biomarker PSYGENET Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. 20554694

2010

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]). 21917409

2012

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET The ADH1B genotype was associated with the frequency and volume of drinking but its associations with binge drinking and problem drinking were less consistent. 22150722

2012

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. 17454860

2007

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol abuse and alcoholism. 11535626

2001

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence. 24553426

2014

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde levels after ethanol consumption, which leads to dysphoric effects, such as facial flushing, nausea, dizziness, and headache ("Asian alcohol phenotype"), which result in an aversion to alcohol and protection against alcohol abuse and alcoholism. 19251111

2009

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men. 24018899

2014

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET The ALDH2*2 allele, detected in nearly half of the subjects, showed an overwhelming protective effect against a high level of alcohol consumption and problem drinking behavior, as determined by the Kurihama Alcoholism Screening Test (KAST). 12211622

2002

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]). 21917409

2012

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene by environment investigations of alcohol phenotypes. 25410943

2014

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.570 Biomarker PSYGENET Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. 20554694

2010

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.570 Biomarker PSYGENET The current study used path analysis (via structural equation modelling) to explore the relationship between the A(1) allele of the D2 dopamine receptor DRD2 gene region, age of problem drinking onset, alcohol expectancy and drinking refusal self-efficacy towards alcohol consumption and dependence severity. 18514919

2008

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.570 Biomarker PSYGENET In this study, we provide additional positive evidence for the association between DRD2/ANKK1 and alcohol outcomes, including frequency of drinking and drinking problems. 22970887

2013

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.570 Biomarker PSYGENET Alcohol abuse and HIV infection: role of DRD2. 25053368

2014

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.570 Biomarker PSYGENET In contrast, no interaction effects were found between the DRD2 allele status and ADHD on severity of problem drinking or drug use. 19344737

2009

Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.530 Biomarker PSYGENET Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. 7943668

1994

Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.530 Biomarker PSYGENET The ADH2*1/*1 and the ADH3*1/*1 genotypes were statistically significantly more common among the patients who abuse alcohol than in the control group. 17454860

2007

Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.530 Biomarker PSYGENET Our findings support that ADH1C Ile may lower the risk of AD and alcohol abuse as well as alcohol-related cirrhosis in pooled populations, with the strongest and most consistent effects in Asians. 22476623

2012

Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.530 Biomarker PSYGENET Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]). 21917409

2012

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.510 Biomarker PSYGENET The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384). 23729673

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.510 Biomarker PSYGENET Alcohol abuse by itself did not have a significant effect on PFC 5-HT(2A) binding and as 5-HT(2A) binding in alcoholics is not different from controls and antagonists may be therapeutic, fewer receptors may result in downstream developmental effects on the brain resulting in a predisposition to alcoholism. 18241316

2008

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.510 Biomarker PSYGENET Variation at the human mu-opioid receptor has been associated with alcohol abuse. 20153935

2010

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.510 Biomarker PSYGENET In contrast, alveolar macrophages from subjects with alcohol abuse had decreased MMP-9 and MMP-2 mRNA expression (p<0.03 and p<0.005, respectively). 17374047

2007