Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 Biomarker LHGDN A role for CA9 as an endogenous marker of tumor hypoxia is currently not supported by available clinical data. 18290322

2008

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN findings show that CA9 is correlated with poor prognosis and malignant phenotype in patients with oesophageal squamous cell carcinoma, and was upregulated by hypoxia 18841153

2008

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN Expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and carbonic anhydrase IX (CA IX) are markers of cellular hypoxia. 17674038

2007

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN Coexpression of HIF-1alpha and CAIX in the epithelium in phyllodes tumors points to epithelial hypoxia, most probably caused by relatively distant blood vessels. 16168127

2005

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN MAPK cascade is involved in the regulation of CA9 gene expression under both hypoxia and high cell density. 15833446

2005

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 Biomarker LHGDN Cell hypoxia activates the capacity of tumor-associated CA9 to acidify extracellular pH. 15556624

2005

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. 12615703

2003

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN mCA IX is a marker of tumor cell hypoxia, and absence of CA IX staining close to microvessels suggests that these vessels are functionally active; pCA IX expression is representative of an aggressive phenotype 12560438

2003

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 AlteredExpression LHGDN Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase. 12154057

2002

Entrez Id: 768
Gene Symbol: CA9
CA9
CUI: C0003130
Disease: Anoxia
Anoxia
0.400 Biomarker LHGDN CA9 might be a marker of clinically important hypoxia. 11705854

2001

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0003130
Disease: Anoxia
Anoxia
0.320 Biomarker LHGDN Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. 18818408

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0003130
Disease: Anoxia
Anoxia
0.320 AlteredExpression LHGDN The amount of ecNOS in the placenta is not deficient in pre-eclampsia, excluding a possible pathogenic role for eNOS in this disease; furthermore, placental hypoxia, which is associated with pre-eclampsia, does not induce an upregulation of ecNOS. 12859429

2004

Entrez Id: 132
Gene Symbol: ADK
ADK
CUI: C0003130
Disease: Anoxia
Anoxia
0.310 AlteredExpression LHGDN role for HIF-1alpha in transcriptional repression of AK in hypoxia 18309031

2008

Entrez Id: 1958
Gene Symbol: EGR1
EGR1
CUI: C0003130
Disease: Anoxia
Anoxia
0.310 AlteredExpression LHGDN Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia 11830539

2002

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN The role of hypoxia inducible factor-1 on the expression of cystic fibrosis transmembrane conductance regulator and chloride and water flux in intestinal cells is reported. 18779379

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN These data suggest that hypoxia enhances the expression of MUC1 through the transcriptional regulation by HIF-1alpha in a human lung epithelial cell line. 19141292

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Results show that many genes regulated by hypoxia and HIF-1alpha show patterns of induction with JMJD (Jumonji-domain containing) 1A and JMJD2B demonstrating robust, and JMJD2C more modest, up-regulation by hypoxia. 18713068

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN PlGF-mediated increased FLAP mRNA expression occurred via activation of phosphoinositide-3 (PI-3) kinase, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and hypoxia inducible factor-1alpha (HIF-1alpha). 18945963

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN an RNA switch in human vascular endothelial growth factor-A mRNA 3'untranslated region that integrates signals from interferon -gamma and hypoxia to regulate VEGFA translation in myeloid cells 19098893

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN results indicate that in progressive but not in stable proteinuric kidney disease, proximal tubular epithelial cells show an attenuated VEGF-A expression despite an activation of intracellular hypoxia response and VEGF signaling pathways 19139726

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN MGr1-Ag/37LRP is actively engaged by hypoxia and represent a novel HIF-1 target. 19123465

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Dual role for hypoxia inducible factor 1 alpha in providing a survival or death signal, based on hypoxia duration, and consider the nuclear transcription factor, CREB, to be a possible target for hypoxic therapy against leukemia disease. 18996491

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN HSP70-2 is transcriptionally upregulated by HIF-1 in cancer cells in response to hypoxia 18844219

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN The transcriptional activation of HIF-1 induced by hypoxia or DFO was visualized by both bioluminescence and scintigraphic reporter gene systems. 18703592

2008

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN Sphingosine kinase 1 is a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells. 18922940

2008