Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.700 Biomarker LHGDN We evaluated herein the effect of PECAM-1 deficiency on development of atherosclerosis in LDL receptor-deficient mice. 18669884

2008

Entrez Id: 3949
Gene Symbol: LDLR
LDLR
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.700 AlteredExpression LHGDN Increased expression of the low-density lipoprotein receptor (LDLR) is generally considered beneficial for reducing plasma cholesterol and atherosclerosis, and its downregulation has been thought to explain the association between apolipoprotein (apo) E4 and increased risk of coronary heart disease in humans. 12969990

2004

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 Biomarker LHGDN Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice. 18079965

2008

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 AlteredExpression LHGDN Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. 18689793

2008

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 AlteredExpression LHGDN Endogenous secretory RAGE but not soluble RAGE is associated with carotid atherosclerosis in type 1 diabetes patients. 18777492

2008

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 Biomarker LHGDN Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. 17220293

2007

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 Biomarker LHGDN RAGE axis: Animal models and novel insights into the vascular complications of diabetes. 15155381

2004

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 PosttranslationalModification LHGDN Homocysteine-mediated PPARalpha,gamma DNA methylation and its potential pathogenic mechanism in monocytes. 18004978

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 Biomarker LHGDN In conclusion, stimulation of CYP27A1 by PPARgamma may represent a key previously unrecognized mechanism by which PPARgamma protects against atherosclerosis. 15533057

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 AlteredExpression LHGDN Although activation of PPARgamma appears to have beneficial effects on atherosclerosis and heart failure, it is still largely uncertain whether PPARgamma ligands prevent the development of cardiovascular diseases. 12861348

2003

Entrez Id: 1593
Gene Symbol: CYP27A1
CYP27A1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.450 Biomarker LHGDN In conclusion, stimulation of CYP27A1 by PPARgamma may represent a key previously unrecognized mechanism by which PPARgamma protects against atherosclerosis. 15533057

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Severe Tangier disease with a novel ABCA1 gene mutation. 18955690

2008

Entrez Id: 5320
Gene Symbol: PLA2G2A
PLA2G2A
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN The role of sPLA(2)-IIA in the perpetuation of atherosclerosis appears to be the missing link between inflammation, activated RAS and lipid peroxidation. 18827909

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN Apolipoprotein C1 and apolipoprotein E are differentially expressed in atheroma of the carotid and femoral artery. 17936795

2008

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN A lack of increase in high molecular weight-adiponectin in macroalbuminuric subjects with metabolic syndrome may exert renal and atherosclerotic risks. 18006102

2008

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation LHGDN Side by side with the decrease in the T-SH levels in the middle-aged and elderly groups as compared to the young, the increase we have observed in other protein oxidation parameters in the groups leading to decreasing PON1 activity might, we think, create a predisposition to atherosclerosis. 18385941

2008

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Inhibition of TLR4 signaling pathway: molecular treatment strategy of periodontitis-associated atherosclerosis. 17681703

2008

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN In conclusion, stimulation of hydrolysis of CE in macrophages induces the expression of ABCA1 gene primarily via the LXR-dependent pathway and can be useful for the prevention of atherosclerosis. 18762171

2008

Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation LHGDN We examined the role of three single nucleotide polymorphisms (SNPs) in the 15-lipoxygenase gene (ALOX15), in atherosclerosis. 18392641

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Rapamycin is associated with high eNOS in low shear regions, i.e. in atherogenic regions, protecting these regions against atherosclerosis, and is associated with a reduction of eNOS at high shear stress affecting vasomotion in these regions. 18079107

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation LHGDN The objective of this study was to investigate the influence of the APOE promoter (-491 A/T, -427 T/C and -219 G/T) and coding region (APOE epsilon2/epsilon3/epsilon4) polymorphisms in atherosclerosis disease by association and linkage disequilibrium analyses. 18219091

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cells. 18270456

2008

Entrez Id: 1535
Gene Symbol: CYBA
CYBA
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells. 18158642

2008

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation LHGDN Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis. 18083122

2008

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation LHGDN To test the hypothesis that allelic variants of the paraoxonase-1 gene are associated with endothelial dysfunction, an early stage of atherosclerosis. 18241625

2008