Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.700 Biomarker LHGDN PECAM-1 influences initiation and progression of atherosclerosis in LDL receptor deficient mice both positively and negatively, and that it does so in a site-specific manner. 18669884

2008

Entrez Id: 3949
Gene Symbol: LDLR
LDLR
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.700 AlteredExpression LHGDN Doubling transfected human Ldlr expression caused severe atherosclerosis with marked accumulation of cholesterol-rich, apoE-poor remnants in mice with human apoE4, but not apoE3, suggesting that the receptor can trap apoE4. 12969990

2004

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 AlteredExpression LHGDN likely that circulating soluble RAGE and endogenous secretory RAGE are distinct markers and that circulating esRAGE levels are associated with the status of early-stage atherosclerosis. 18777492

2008

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 Biomarker LHGDN endothelial RAGE and its ligands mediate vascular and inflammatory stresses that culminate in atherosclerosis in the vulnerable vessel wall 18079965

2008

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 AlteredExpression LHGDN Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. 18689793

2008

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 Biomarker LHGDN We found an association between AGT and blood pressure, atherosclerosis and white matter lesions (WML)/, we found synergistic effects between AGT and AT1R on the development of WML. 17220293

2007

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 Biomarker LHGDN Review/is an amplification step in vascular inflammation and acceleration of atherosclerosis. 15155381

2004

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 GeneticVariation LHGDN The APOE epsilon2 allele was in linkage disequilibrium with the -427C allele in atherosclerosis diseases, and the -219T allele was associated with the epsilon4 allele in the ischemia heart disease group. 18219091

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 AlteredExpression LHGDN The expression of apo C1 and apo E are closely associated with the susceptibility to the pathogenesis of atherosclerosis 17936795

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 GeneticVariation LHGDN The specific Apolipoprotein E allele showed higher levels of Matrix Metalloproteinase 9 in epsilon 2 carriers compared to the non- epsilon 2 carriers of the patient group and large artery atherosclerosis subgroup. 18094576

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 GeneticVariation LHGDN ApoE epsilon4 allele should be screened in patients with femoropopliteal atherosclerosis 17126308

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 AlteredExpression LHGDN Intravenous administration of AAV2/7- and AAV2/8-apoE vectors effectively mediated robust and sustained hepatic-specific expression of apoE and completely prevented atherosclerosis at 1 year. 16763161

2006

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 GeneticVariation LHGDN APOE*4 allele has an age-dependent association with atherosclerosis, increasing susceptibility among young to middle age Argentine males 16201140

2005

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 GeneticVariation LHGDN The ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype 12754278

2003

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 Biomarker LHGDN This review examines key scientific advances which focus on possible therapeutic strategies encompassing the use of apoE in the amelioration of atherosclerosis, based on its direct effects on the vascular wall. 12769659

2003

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 Biomarker LHGDN Hyperlipidemia in APOE*3 Leiden transgenic mice resulted in a significant increase in accelerated atherosclerosis in vein grafts. 12364385

2002

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.500 GeneticVariation LHGDN Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional genotype 12213863

2002

Entrez Id: 1593
Gene Symbol: CYP27A1
CYP27A1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.450 Biomarker LHGDN stimulation of CYP27A1 by PPARgamma may represent a key previously unrecognized mechanism by which PPARgamma protects against atherosclerosis 15533057

2005

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Maternal type 1 diabetes increases the foetal plasma CRP concentration and thus might predispose the offspring to development of atherosclerosis. 18551710

2008

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN ABC-A1 may be more than a determinant of HDL-cholesterol which may provide a link between components of the metabolic syndrome and atherosclerosis. 18220685

2008

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Resuslts show that increased serum HMW-adiponectin by unknown mechanisms, at abstract least independent of WC, might help protect against renal and atherosclerosis risks in macroalbuminuric MS-. 18006102

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN hypoxia and hypoxia-induced VEGF expression are involved in the pathogenesis of progressive atherosclerosis. 18270456

2008

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 AlteredExpression LHGDN Stimulation of hydrolysis of cholesteryl ester in macrophages induces the expression of ABCA1 gene primarily via the LXR-dependent pathway and can be useful for the prevention of atherosclerosis. 18762171

2008

Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 GeneticVariation LHGDN ALOX15 single nucleotide polymorphisms (SNPs) have a possible role in focal atherosclerosis plaque formation. 18392641

2008

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker LHGDN Measures of inflammation, such as CRP, and indices of atherosclerosis, such as coronary calcium store, are likely to provide distinct information regarding cardiovascular risk 18810717

2008