Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD This suggestion may also provide a rational explanation for a previous unexpected finding that cigarette smoking appears to reduce the breast cancer risk of BRCA2 mutation carriers. 14981540

2004

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD BRCA2 is a breast cancer susceptibility gene. 14981540

2004

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD Inherited BRCA2 mutations predispose individuals to breast cancer and increase risk at other sites. 11215675

2001

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD Recent studies have suggested a role for the APC I1307K allele as a low-penetrance breast cancer susceptibility gene that enhances the phenotypic effects of BRCA1 and BRCA2 mutations. 11215675

2001

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker MGD

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.800 Biomarker MGD Caveolin-1 (Cav-1) loss-of-function mutations are exclusively associated with estrogen receptor-positive (ER(+)) human breast cancers. 19342371

2009

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.800 Biomarker MGD To dissect the role of Cav-1 loss-of-function in the pathogenesis of human breast cancers, we used Cav-1(-/-) null mice as a model system. 19342371

2009

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.800 Biomarker MGD

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Interestingly, the expression levels of STAT1 in the tumor-infiltrating stromal cells remain elevated, indicating that single-cell resolution analysis of STAT1 level in primary breast cancer biopsies is necessary for accurate assessment. 22264274

2013

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Forty-five percent (37/83) of human ERα+ and 22% (17/78) of ERα- breast cancers display undetectable or low levels of STAT1 expression in neoplastic cells. 22264274

2013

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Spontaneous mammary tumors that develop in STAT1-/- mice closely recapitulate the progression, ovarian hormone responsiveness, and molecular characteristics of human luminal breast cancer, the most common subtype of human breast neoplasms, and thus represent a valuable platform for testing novel treatments and detection modalities. 22264274

2013

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD In addition, the molecular signature of the STAT1-/- mammary tumors overlaps closely to that of human luminal breast cancers. 22264274

2013

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Herein, we show that a subset of human breast cancers display reduced STAT1 expression and that mice lacking STAT1 surprisingly develop ERα+/PR+ mammary tumors. 22264274

2013

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Our findings demonstrate that STAT1 suppresses mammary tumor formation and its expression is frequently lost during breast cancer progression. 22264274

2013

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta. 18209032

2008

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways. 18493980

2008

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN. 17475277

2007

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia. 17078933

2006

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes. 12223448

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.300 Biomarker MGD Cancer stemness in Wnt-driven mammary tumorigenesis. 23955540

2014

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.300 Biomarker MGD A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. 19578404

2009