Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 894
Gene Symbol: CCND2
CCND2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.610 Biomarker CTD_human For example, genes involved in inflammation and matrix proteases and a cell cycle regulator gene, cyclin D2, were highly expressed in colon cancers. 15059925

2004

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Therapeutic CTD_human These results suggest that the PPARgamma agonist, troglitazone, inhibits colon cancer cell growth via inactivation of NF-kappaB by suppressing GSK-3beta activity. 20540935

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human Polymorphisms in IL1B, IL1RN, and VEGFA as well as IL1B/IL1RN haplotype analysis may serve as molecular markers for tumor recurrence in stage II colon cancer, indicating that the analysis of angiogenesis-related gene polymorphisms may help to identify patient subgroups at high risk for tumor recurrence. 18987561

2009

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. 19147571

2009

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. 17404573

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker CTD_human Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. 10223192

1999

Entrez Id: 8797
Gene Symbol: TNFRSF10A
TNFRSF10A
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.520 Biomarker CTD_human Prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in adjuvantly treated stage III colon cancer patients. 17075118

2006

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis. 26335331

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916

2015

Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells. 25030372

2014

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Our findings suggest that LSD1/CoREST acts as a colon cancer oncogene by epigenetically silencing MLH1 and also identify the LSD1/CoREST complex as a potential target for therapy. 25043185

2014

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. 25200834

2014

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human In this study, we demonstrate that K-Ras, a frequently altered oncogene in human cancers including pancreatic cancer (about 80%), colon cancer (45%) and lung cancer (45%), suppresses p53. 19424582

2009

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human This K-Ras tumor phenotype was associated with attenuated signaling through the MAPK pathway, and human colon cancer cells expressing mutant K-Ras were hypersensitive to inhibition of Raf, but not Mek. 18372904

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. 17192441

2007

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. 17192441

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. 17192441

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in adjuvantly treated stage III colon cancer patients. 17075118

2006

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. 12839936

2003

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin. 12800193

2003

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene. 12034317

2002

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats. 10813127

2000

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice. 10383901

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Genetic alterations in rat colon tumors induced by heterocyclic amines. 8608549

1996

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 7846077

1995