Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.500 Biomarker RGD LLI may protect the brain by upregulating Akt, pAkt, pBAD, and Bcl-2 expression and downregulating caspase 9 and caspase 3 expression following transient cerebral ischemia. 21712070

2011

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.500 Therapeutic RGD The protective effect of SCR(15-18) on cerebral ischemia-reperfusion injury. 22004711

2011

Entrez Id: 27429
Gene Symbol: HTRA2
HTRA2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.500 Therapeutic RGD UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats. 19462455

2009

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.500 Biomarker RGD Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals. 15246841

2004

Entrez Id: 3717
Gene Symbol: JAK2
JAK2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.310 Biomarker RGD SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. 23764464

2013

Entrez Id: 4000
Gene Symbol: LMNA
LMNA
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.300 Biomarker RGD Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. 17683050

2007

Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.300 Biomarker RGD TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. 15781474

2005

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.240 Biomarker RGD Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. 19623195

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Therapeutic RGD Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats. 24773551

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Therapeutic RGD Therapeutic effect of Ginkgo biloba polysaccharide in rats with focal cerebral ischemia/reperfusion (I/R) injury. 24053818

2013

Entrez Id: 7450
Gene Symbol: VWF
VWF
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Therapeutic RGD Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia. 22771326

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Therapeutic RGD Melatonin reduced the elevated matrix metalloproteinase-9 level in a rat photothrombotic stroke model. 23046750

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. 19221220

2009

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. 18973594

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain. 18378216

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia. 11412877

2001

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. 11592852

2001

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Therapeutic RGD Cdk5 is required for the neuroprotective effect of transforming growth factor-β1 against cerebral ischemia-reperfusion. 28254431

2017

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Therapeutic RGD Epigallocatechin Gallate Extends the Therapeutic Window of Recombinant Tissue Plasminogen Activator Treatment in Ischemic Rats. 26851971

2016

Entrez Id: 361
Gene Symbol: AQP4
AQP4
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Therapeutic RGD Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats. 24773551

2014

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 ModifyingMutation RGD Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. 25098324

2014

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Therapeutic RGD Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia. 23884942

2013

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. 23764464

2013

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Therapeutic RGD Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. 22509406

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Post-insult ibuprofen treatment attenuates damage to the serotonergic system after hypoxia-ischemia in the immature rat brain. 23147509

2012