×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer.
19088039 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
LHGDN
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.
18326857 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.
17128412 2007
×
Entrez Id: 324
Gene Symbol: APC
APC
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Truncated APC is required for cell proliferation and DNA replication.
16450383 2006
×
Entrez Id: 324
Gene Symbol: APC
APC
Colonic Neoplasms
0.600
Biomarker
LHGDN
Examination of actin and microtubule dependent APC localisations in living mammalian cells.
16423286 2006
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
LHGDN
RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility.
17178865 2006
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
LHGDN
The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.
16203768 2005
×
Entrez Id: 324
Gene Symbol: APC
APC
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.
15548520 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways.
15896711 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Marked increased expression of cyclooxygenase 2 (COX-2 ), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia .
15574495 2004
×
Entrez Id: 324
Gene Symbol: APC
APC
Colonic Neoplasms
0.600
GeneticVariation
LHGDN
Colorectal cancer prevention.
15375803 2004
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways.
12839952 2003
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2.
12767532 2003
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
LHGDN
Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells.
12598658 2003
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a.
14675489 2003
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
LHGDN
Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer.
12124799 2002
×
Entrez Id: 324
Gene Symbol: APC
APC
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer.
11751382 2001
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colonic Neoplasms
0.600
AlteredExpression
LHGDN
Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer.
11705852 2001
×
Entrez Id: 596
Gene Symbol: BCL2
BCL2
Colonic Neoplasms
0.560
Biomarker
LHGDN
Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2.
16227396 2005
×
Entrez Id: 596
Gene Symbol: BCL2
BCL2
Colonic Neoplasms
0.560
AlteredExpression
LHGDN
Low frequency of bcl-2 expression in large non-polypoid colonic neoplasms .
15303767 2004
×
Entrez Id: 596
Gene Symbol: BCL2
BCL2
Colonic Neoplasms
0.560
AlteredExpression
LHGDN
Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway.
15314290 2004
×
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
Colonic Neoplasms
0.540
AlteredExpression
LHGDN
Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo.
17224907 2007
×
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
Colonic Neoplasms
0.540
AlteredExpression
LHGDN
Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.
17186550 2007
×
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
Colonic Neoplasms
0.540
Biomarker
LHGDN
Effect of DPC4 gene on invasion and metastasis of colorectal carcinoma cells.
17151782 2006
×
Entrez Id: 4609
Gene Symbol: MYC
MYC
Colonic Neoplasms
0.530
AlteredExpression
LHGDN
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.
16543245 2006