Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Ghrelin effects expression of several genes associated with depression-like behavior. 25286107

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction. 25315113

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. 25583186

2015

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Among all candidate substrates, DPP4 displays highest affinity for NPY, an endogenous anxiolytic neurotransmitter that is suggested as a candidate biomarker in post-traumatic stress disorder (PTSD) and depression. 25635612

2015

Entrez Id: 6530
Gene Symbol: SLC6A2
SLC6A2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients. 25650523

2015

Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET We report that BDNF and selective tyrosine kinase receptor B (TrkB) agonist 7,8-dihydroxyflavone (DHF) activated the TrkB receptor to facilitate two forms of eCB-mediated synaptic depression, depolarization-induced suppression of inhibition (DSI), and long-term depression (I-LTD) of IPSCs in ventral tegmental area dopamine neurons in mouse midbrain slices. 25762688

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Network modeling and animal experiments suggest that these genetic differences in GR-induced transcriptional activation may mediate the risk for depression and other psychiatric disorders by altering a network of functionally related stress-sensitive genes in blood and brain. 26050039

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Pregabalin showed the analgesic effects but had no effects on either depression or the BDNF pathway. 25283187

2015

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test. 25578258

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis. 24933348

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET These observations demonstrate that IL6 directly controls SERT levels and consequently serotonin reuptake and identify STAT3-dependent regulation of SERT as conceivable neurobiological substrate for the involvement of IL6 in depression. 25760924

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET However, the expression of DNMT1/3A, EZH2 and IL-6 genes increases with increasing Hospital Anxiety and Depression Scale-Anxiety scores in the anxious cohort only. 25350786

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. 25510949

2015

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Our results confirm that the risk of depression conferred by childhood maltreatment is modified by variation at both SERT and BDNF genes. 25510949

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Ketamine suppressed the production of the only established depression-relevant proinflammatory cytokines, IL-6 and TNFα. 25903726

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Previously, we reported that IL-1 receptor antagonist (IL-1Ra) knockout (KO) mice, which lacked IL-1Ra molecules that antagonize the IL-1 receptor, showed anti-depression-like behavior via adrenergic modulation at the age of 8 weeks. 26002078

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Methylation in CpG sites in candidate genes were not predictors of depression at significance levels corrected for whole genome testing, but maltreated and control children did have significantly different β values after Bonferroni correction at multiple methylation sites in these candidate genes (e.g., BDNF, NR3C1, FKBP5). 24655651

2014

Entrez Id: 7166
Gene Symbol: TPH1
TPH1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET The results indicate that there exists possible interrelation between TH and TPH gene expression and epigenetic histone acetylation in CUS-induced depressive rats, which at least partly contributes to the etiology of depression. 24495952

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity. 24931706

2014

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent studies identifying the very early postnatal period as highly susceptible to this programming. 24630468

2014

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoid receptor sensitivity, stress response regulation, and depression risk in traumatized subjects, with most consistent findings reported for the functional variant rs1360780. 25522420

2014

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study. 25422958

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression. 24314147

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2014