Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700 Biomarker MGD Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. 22297672

2012

Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700 Biomarker MGD Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. 12925730

2003

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker MGD IFN-gamma affects homing of diabetogenic T cells. 11714835

2001

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD Late developmental plasticity in the T helper 17 lineage. 19119024

2009

Entrez Id: 2572
Gene Symbol: GAD2
GAD2
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD To investigate the role of glutamic acid decarboxylase 65 (GAD65) in the development of the Type 1 diabetes of non-obese diabetic (NOD) mice, we analysed and characterised NOD mice with targeted disruption of the GAD65 gene. 14676944

2004

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD Autoimmune diabetes is blocked in Stat4-deficient mice. 15041039

2004

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. 12709397

2003

Entrez Id: 3565
Gene Symbol: IL4
IL4
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD Interleukin-4 deficiency does not exacerbate disease in NOD mice. 9703318

1998

Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. 9308961

1997

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD

Entrez Id: 57818
Gene Symbol: G6PC2
G6PC2
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD

Entrez Id: 5799
Gene Symbol: PTPRN2
PTPRN2
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker MGD

Entrez Id: 3651
Gene Symbol: PDX1
PDX1
Diabetes Mellitus, Insulin-Dependent
0.260 Biomarker MGD

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
Diabetes Mellitus, Insulin-Dependent
0.250 Biomarker MGD

Entrez Id: 3554
Gene Symbol: IL1R1
IL1R1
Diabetes Mellitus, Insulin-Dependent
0.240 Biomarker MGD IL-1 receptor deficiency slows progression to diabetes in the NOD mouse. 14693705

2004

Entrez Id: 952
Gene Symbol: CD38
CD38
Diabetes Mellitus, Insulin-Dependent
0.220 Biomarker MGD Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. 16585549

2006

Entrez Id: 6402
Gene Symbol: SELL
SELL
Diabetes Mellitus, Insulin-Dependent
0.220 Biomarker MGD Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors. 14662758

2004

Entrez Id: 1019
Gene Symbol: CDK4
CDK4
Diabetes Mellitus, Insulin-Dependent
0.220 Biomarker MGD Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. 10319860

1999

Entrez Id: 356
Gene Symbol: FASLG
FASLG
Diabetes Mellitus, Insulin-Dependent
0.220 Biomarker MGD

Entrez Id: 7292
Gene Symbol: TNFSF4
TNFSF4
Diabetes Mellitus, Insulin-Dependent
0.210 Biomarker MGD Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. 14662903

2003

Entrez Id: 5551
Gene Symbol: PRF1
PRF1
Diabetes Mellitus, Insulin-Dependent
0.210 Biomarker MGD Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. 10946317

2000

Entrez Id: 11213
Gene Symbol: IRAK3
IRAK3
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker MGD IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice. 24696448

2014

Entrez Id: 1869
Gene Symbol: E2F1
E2F1
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker MGD Consistent with these observations, E2f1 homozygous mutant NOD mice were highly predisposed to the development of IDDM and SS. 15470032

2004

Entrez Id: 3460
Gene Symbol: IFNGR2
IFNGR2
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker MGD IFN-gamma affects homing of diabetogenic T cells. 11714835

2001

Entrez Id: 3460
Gene Symbol: IFNGR2
IFNGR2
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker MGD Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. 11118001

2000