Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker RGD HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus. 19252740

2009

Entrez Id: 5078
Gene Symbol: PAX4
PAX4
Diabetes Mellitus, Non-Insulin-Dependent
1.000 ModifyingMutation RGD The R121W mutation in PAX4 is a predisposing factor for the development of type 2 diabetes in Okinawans. 12604352

2003

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker MGD Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. 12606498

2003

Entrez Id: 208
Gene Symbol: AKT2
AKT2
Diabetes Mellitus, Non-Insulin-Dependent
0.960 Biomarker MGD Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). 11387480

2001

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart. 24681897

2014

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Therapeutic RGD Glucokinase activators (GKAs) are currently being developed as new therapies for type 2 diabetes and have been shown to enhance beta cell survival and proliferation in vitro. 22234649

2012

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes? 22001674

2011

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD In summary, we show that, in a rodent model of T2DM, voluntary exercise decreases circulating markers of inflammation and oxidative stress and lowers hepatic JNK activation and Ser(307)-phosphorylated insulin receptor substrate-1. 19996384

2010

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD Defect in glucokinase translocation in Zucker diabetic fatty rats. 15138155

2004

Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker MGD Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. 9566924

1998

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker MGD Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. 8530440

1995

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker MGD Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. 7969452

1994

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker MGD Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. 9312184

1997

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker MGD The male GLUT4 +/- mice represent a good model for studying the development of NIDDM without the complications associated with obesity. 9334720

1997

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-β1 in the myocardium of rats with diabetes. 24613393

2014

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Therapeutic RGD Duodenal-jejunal bypass surgery up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic Goto-Kakizaki rats. 23700236

2013

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD We show robust differences in TCF7L2 expression between healthy controls and models of T2DM. 19386626

2009

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Therapeutic RGD TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. 19251743

2009

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. 19340286

2009

Entrez Id: 3651
Gene Symbol: PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Development of beta-cells in the native pancreas after pancreas allo-transplantation in the Spontaneously Diabetic Torii rat. 17764693

2008

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. 18288891

2008

Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. 17911348

2007

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. 17050616

2007

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Reduced expression of insulin receptors in the kidneys of insulin-resistant rats. 17855644

2007

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Thus, p27(Kip1) contributes to beta-cell failure during the development of type 2 diabetes in Irs2(-/-) and Lepr(-/-) mice and represents a potential new target for the treatment of this condition. 15685168

2005