×
Entrez Id:
3172
Gene Symbol:
HNF4A
HNF4A
Diabetes Mellitus, Non-Insulin-Dependent
1.000
Biomarker
RGD
HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus.
19252740
2009
×
Entrez Id:
5078
Gene Symbol:
PAX4
PAX4
Diabetes Mellitus, Non-Insulin-Dependent
1.000
ModifyingMutation
RGD
The R121W mutation in PAX4 is a predisposing factor for the development of type 2 diabetes in Okinawans.
12604352
2003
×
Entrez Id:
5506
Gene Symbol:
PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000
Biomarker
MGD
Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance.
12606498
2003
×
Entrez Id:
208
Gene Symbol:
AKT2
AKT2
Diabetes Mellitus, Non-Insulin-Dependent
0.960
Biomarker
MGD
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
11387480
2001
×
Entrez Id:
3767
Gene Symbol:
KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
RGD
Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart.
24681897
2014
×
Entrez Id:
2645
Gene Symbol:
GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Therapeutic
RGD
Glucokinase activators (GKAs) are currently being developed as new therapies for type 2 diabetes and have been shown to enhance beta cell survival and proliferation in vitro.
22234649
2012
×
Entrez Id:
3667
Gene Symbol:
IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
RGD
Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes ?
22001674
2011
×
Entrez Id:
3667
Gene Symbol:
IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
RGD
In summary, we show that, in a rodent model of T2DM , voluntary exercise decreases circulating markers of inflammation and oxidative stress and lowers hepatic JNK activation and Ser(307)-phosphorylated insulin receptor substrate-1 .
19996384
2010
×
Entrez Id:
2645
Gene Symbol:
GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
RGD
Defect in glucokinase translocation in Zucker diabetic fatty rats.
15138155
2004
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
MGD
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.
9566924
1998
×
Entrez Id:
2645
Gene Symbol:
GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
MGD
Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.
8530440
1995
×
Entrez Id:
3667
Gene Symbol:
IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
MGD
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
7969452
1994
×
Entrez Id:
6517
Gene Symbol:
SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800
Biomarker
MGD
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.
9312184
1997
×
Entrez Id:
6517
Gene Symbol:
SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800
Biomarker
MGD
The male GLUT4 +/- mice represent a good model for studying the development of NIDDM without the complications associated with obesity.
9334720
1997
×
Entrez Id:
7040
Gene Symbol:
TGFB1
TGFB1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
RGD
The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-β1 in the myocardium of rats with diabetes.
24613393
2014
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Therapeutic
RGD
Duodenal-jejunal bypass surgery up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic Goto-Kakizaki rats.
23700236
2013
×
Entrez Id:
6934
Gene Symbol:
TCF7L2
TCF7L2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
RGD
We show robust differences in TCF7L2 expression between healthy controls and models of T2DM .
19386626
2009
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Therapeutic
RGD
TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.
19251743
2009
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
RGD
Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown.
19340286
2009
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
RGD
Development of beta-cells in the native pancreas after pancreas allo-transplantation in the Spontaneously Diabetic Torii rat.
17764693
2008
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
18288891
2008
×
Entrez Id:
3630
Gene Symbol:
INS
INS
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
17911348
2007
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
RGD
Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.
17050616
2007
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
RGD
Reduced expression of insulin receptors in the kidneys of insulin-resistant rats.
17855644
2007
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Thus, p27(Kip1) contributes to beta-cell failure during the development of type 2 diabetes in Irs2 (-/-) and Lepr(-/-) mice and represents a potential new target for the treatment of this condition.
15685168
2005