Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker RGD HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus. 19252740

2009

Entrez Id: 5078
Gene Symbol: PAX4
PAX4
Diabetes Mellitus, Non-Insulin-Dependent
1.000 ModifyingMutation RGD The R121W mutation in PAX4 is a predisposing factor for the development of type 2 diabetes in Okinawans. 12604352

2003

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart. 24681897

2014

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Therapeutic RGD Glucokinase activators (GKAs) are currently being developed as new therapies for type 2 diabetes and have been shown to enhance beta cell survival and proliferation in vitro. 22234649

2012

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes? 22001674

2011

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD In summary, we show that, in a rodent model of T2DM, voluntary exercise decreases circulating markers of inflammation and oxidative stress and lowers hepatic JNK activation and Ser(307)-phosphorylated insulin receptor substrate-1. 19996384

2010

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker RGD Defect in glucokinase translocation in Zucker diabetic fatty rats. 15138155

2004

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-β1 in the myocardium of rats with diabetes. 24613393

2014

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Therapeutic RGD Duodenal-jejunal bypass surgery up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic Goto-Kakizaki rats. 23700236

2013

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD We show robust differences in TCF7L2 expression between healthy controls and models of T2DM. 19386626

2009

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Therapeutic RGD TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. 19251743

2009

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. 19340286

2009

Entrez Id: 3651
Gene Symbol: PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Development of beta-cells in the native pancreas after pancreas allo-transplantation in the Spontaneously Diabetic Torii rat. 17764693

2008

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. 17050616

2007

Entrez Id: 3643
Gene Symbol: INSR
INSR
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Reduced expression of insulin receptors in the kidneys of insulin-resistant rats. 17855644

2007

Entrez Id: 11132
Gene Symbol: CAPN10
CAPN10
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD These results suggest that gene expression in WBC could be a useful screening system for predicting the incidence of type 2 diabetes before onset in OLETF rats, and that CAPN10 represents a potential candidate gene for predicting type 2 diabetes in human. 14646187

2003

Entrez Id: 11132
Gene Symbol: CAPN10
CAPN10
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Comparative mapping between human and rat indicated that the Nidd8/of genomic region, near D9rat21 on rat chromosome 9, contains the calpain10 (Capn10) gene, which is putative type 2 diabetes-susceptibility gene in humans. 14658759

2003

Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker RGD Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat. 12607610

2002

Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 Biomarker RGD The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins. 23032698

2013

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Therapeutic RGD Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes. 23731386

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Therapeutic RGD Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism. 22824914

2012

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker RGD Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats. 21155820

2011

Entrez Id: 3953
Gene Symbol: LEPR
LEPR
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker RGD Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat. 23154293

2011

Entrez Id: 3240
Gene Symbol: HP
HP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Therapeutic RGD Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. 19996384

2010

Entrez Id: 7124
Gene Symbol: TNF
TNF
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker RGD We hypothesized that impairment in coronary endothelial function in type 2 diabetes is due to the overexpression of TNF and TNF receptors (TNFRs). 20559450

2010