Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.800 Biomarker RGD Protective effect of oxymatrine on chronic rat heart failure. 21691940

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD Increasing the expression of GTP cyclohydrolase 1, the rate-limiting enzyme in the de novo biosynthesis of tetrahydrobiopterin, exercise training couples endothelial nitric oxide synthase, reduces oxidative stress, and increases nitric oxide bioavailability and sensitivity in coronary arteries of heart failure rats. 29351461

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD ExT reduced by 59% TNF-α level in Tr-HF group (MD -1.7; 95% CI -2.9 to -0.3) and increased IL-10 (MD 15; 95% CI 11-26) when compared with the Sed-HF group. 28939262

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD This study examined the effects of exercise training (ExT) upon concentration of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in the gastrocnemius of rats with heart failure (HF) induced by left coronary artery ligation. 28939262

2018

Entrez Id: 156
Gene Symbol: GRK2
GRK2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD (-)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of β1 adrenoceptor via GRK2 in experimental heart failure. 29247373

2018

Entrez Id: 4878
Gene Symbol: NPPA
NPPA
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure. 23931972

2013

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Angiotensin-converting enzyme inhibition promotes coronary angiogenesis in the failing heart of Dahl salt-sensitive hypertensive rats. 22123369

2011

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD To investigate the possible effects of telmisartan and losartan on cardiac function in adriamycin (ADR)-induced heart failure in rats, and to explore the changes in plasma level of angiotensin-(1-7)[Ang-(1-7)] and myocardial expression of angiotensin II type 1/2 receptors (AT(1)R / AT(2)R) and Mas receptor caused by the two drugs. 21963897

2011

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression. 21963897

2011

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Prolonged treatment with beta-blocker carvedilol in combination with ACE inhibitor perindopril may improve the hemodynamic parameters, enhance Ca(2+) pump activity and increase the density of RyR2 of myocardial SR more effectively than either monotherapy in preventing and treating chronic heart failure following myocardial infarction. 19620082

2009

Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor. 19587314

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD SHR displayed early stage of heart failure as shown by increased heart weight/body weight ratio and relative wall thickness by echocardiography, downregulated myocardial beta(1)-adrenoceptor, and upregulated myocardial brain natriuretic peptide and interleukin-6 (IL6). 18280594

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Role of inflammatory cytokines and chemoattractants in the rat model of streptozotocin-induced diabetic heart failure. 18999900

2008

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. 17582388

2007

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure. 15894569

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats. 15210453

2004

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Therapeutic RGD Tumor necrosis factor-alpha (TNF-alpha) probably affects the pathogenesis of heart failure. 11668085

2001

Entrez Id: 156
Gene Symbol: GRK2
GRK2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Importantly, cardiac dysfunction was preceded by elevated betaARK1 levels and activity, thus suggesting that betaARK1 may be a precipitating factor in the transition from hypertension-induced compensatory cardiac hypertrophy to HF. 9931137

1999

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart. 10199843

1999

Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Increased plasma levels and blunted effects of brain natriuretic peptide in rats with congestive heart failure. 1831369

1991

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.590 Biomarker RGD Our novel findings of increased cardiac CNTF and cardiopulmonary MCP-1 mRNA indicate a role for these factors in the pathogenesis of HF. 12950323

2003

Entrez Id: 2660
Gene Symbol: MSTN
MSTN
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker RGD However, the expression of myostatin in chronic heart failure resulting from volume-overload and after treatment with beta-blockers is little known. 16968467

2006

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.560 Therapeutic RGD Here, we developed a rat model of heart failure to investigate whether a long-term induction of HO-1 by chronic hemin administration exerted protective effects. 23592614

2013

Entrez Id: 155
Gene Symbol: ADRB3
ADRB3
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.520 Biomarker RGD Testosterone modulation of cardiac β-adrenergic signals in a rat model of heart failure. 21549119

2011

Entrez Id: 3357
Gene Symbol: HTR2B
HTR2B
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.500 Biomarker RGD Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. 17936780

2007