Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Sedentary CRF rats exhibited azotemia, hypertension, anemia, oxidative stress, activation of NF-kappaB and upregulations of reactive oxygen species-generating enzyme, NAD(P)H oxidase, MCP-1, cyclooxygenase-2 (COX-2), and PAI-1 in LV. 18797164

2009

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Although compelling evidence of a beneficial effect exists for the use of angiotensin-converting enzyme inhibitors (ACEIs) and low-protein diets, there is little evidence on whether carbon adsorbent has an effect on retardation of the progression of CRF. 14586729

2003

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker RGD Our findings indicate localized expression of MCP-1 in proximal tubular cells in the remnant kidney and suggest that MCP-1 in proximal tubular cells is involved in tubulointerstitial damage in chronic kidney failure associated with glomerular hypertension. 12080327

2002

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.590 Biomarker RGD Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate. 10919844

2000

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.580 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.550 Biomarker RGD Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. 20631677

2011

Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.530 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 1535
Gene Symbol: CYBA
CYBA
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.530 Biomarker RGD Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110

2009

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Therapeutic RGD An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. 26903149

2017

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Biomarker RGD Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction. 18077597

2008

Entrez Id: 873
Gene Symbol: CBR1
CBR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Effect of experimental kidney disease on the functional expression of hepatic reductases. 25332430

2015

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. 21119529

2011

Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. 19878707

2010

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD In CRF rats, a twofold increase in SREBP-2 mRNA level, as well as in mature SREBP-2 protein abundance was found, when compared to control animals. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Despite increased SREBP-2 gene expression we found LDL-receptor mRNA level to be lower than in controls, suggesting SREBP-2 independent mechanisms of LDL-receptor transcriptional regulation in CRF rats. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Increased gene expression of liver SREBP-2 in experimental chronic renal failure. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Therefore, increased level of SREBP-2 could be responsible for hypercholesterolemia, which is observed in experimental chronic renal failure (CRF). 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD We conclude that experimental CRF is associated with increased liver SREBP-2 gene expression. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD This study was designed primary to evaluate the impact of experimental CRF (5/6 nephrectomy model) on rat liver SREBP-2 gene expression. 16814791

2007

Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Renal tissue abundance of gp91(phox) subunit of NAD(P)H oxidase was elevated in the untreated CRF group and was partially reduced in the iron dextran-treated CRF group. 15550752

2004

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 SusceptibilityMutation RGD Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy. 29018182

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD The administration of AST-120 to CRF rats significantly increased urine levels of NOx and the expression of glomerular eNOS and tubulointerstitial nNOS. 18089446

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Urine levels of NOx and the expression of glomerular eNOS and tubulointerstitial nNOS were significantly decreased in CRF rats compared with normal rats. 18089446

2008

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.290 Biomarker RGD Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats. 23548814

2013