Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.800 GeneticVariation LHGDN We analyzed TP53 mutations in 193 CLL patients by denaturing high performance liquid chromatography in combination with direct DNA sequencing and a TP53 resequencing research microarray. 18843282

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.800 GeneticVariation LHGDN Out of the 95 patients with CLL, ATM gene deletion was found in 9 (9.5%) patients, TP53 gene deletion in 16 (16.8%) cases. 18035414

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.800 GeneticVariation LHGDN The overexpression of "delta ex6" p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies. 17688945

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.800 AlteredExpression LHGDN We studied 126 well-characterized CLL patients by direct sequencing and DHPLC to detect TP53 mutations (exons 2-11). 18689542

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.800 GeneticVariation LHGDN Further studies are required to understand the role of SNPs in the p53 pathway in CLL. 17981213

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.800 GeneticVariation LHGDN Translocations or isochromosome formations at sites of low-copy DNA repeats in 17p10 to 17p12 appear to be the mechanism for the loss of TP53 in B-CLL. 16737921

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.800 Biomarker LHGDN Thus, p53 appears to be part of the survival pathway induced by alpha4beta1 ligation and may contribute to the progressive drug resistance in B-CLL. 14623330

2003

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.700 GeneticVariation LHGDN Out of the 95 patients with CLL, ATM gene deletion was found in 9 (9.5%) patients, TP53 gene deletion in 16 (16.8%) cases. 18035414

2008

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.700 Biomarker LHGDN ATM mutations in B-cell chronic lymphocytic leukemia. 14754616

2004

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.700 GeneticVariation LHGDN To examine this proposition further we have screened the ATM gene for mutations in CLLs from 61 individuals in 29 families. 12091354

2002

Entrez Id: 28444
Gene Symbol: IGHV3-21
IGHV3-21
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.600 AlteredExpression LHGDN The first one (7 of 16 cases) carried a similar HCDR3 amino acid sequence (common-HCDR3 subset), virtually identical to the Scandinavian IGHV3-21 CLL. 15466924

2005

Entrez Id: 5027
Gene Symbol: P2RX7
P2RX7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.590 GeneticVariation LHGDN Activation of the P2X7 receptor leads to apoptosis of lymphocytes in individuals with CLL, and reduced function of this receptor has an anti-apoptotic effect, resulting in an increase in B-cell numbers. 11943260

2002

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.500 Biomarker LHGDN Surface expression of Bcl-2 in chronic lymphocytic leukemia and other B-cell leukemias and lymphomas without a breakpoint t(14;18). 18633450

2008

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.500 GeneticVariation LHGDN Prognostic assessment of BCL2-938C>A polymorphism in chronic lymphocytic leukemia. 18156504

2008

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.500 AlteredExpression LHGDN In CD19+ B-CLL cells, the Bax/Bcl-2 ratio was lower than in the CD19+ normal counterpart (1.3 versus 3.51; P<.05), mainly due to a Bcl-2 over expression (17.65 versus 9.02; P<.001). 17118768

2006

Entrez Id: 3676
Gene Symbol: ITGA4
ITGA4
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 Biomarker LHGDN Our observations indicate CD49d >or=30% as a new marker for the initial prognostic assessment of Binet A chronic lymphocytic leukemia. 18641015

2008

Entrez Id: 3676
Gene Symbol: ITGA4
ITGA4
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 AlteredExpression LHGDN These findings support the introduction of CD49d detection in routine prognostic assessment of CLL patients, and suggest both pathogenetic and therapeutic implications for CD49d expression in CLL. 17959854

2008

Entrez Id: 921
Gene Symbol: CD5
CD5
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 Biomarker LHGDN Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. 17878328

2007

Entrez Id: 3676
Gene Symbol: ITGA4
ITGA4
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 Biomarker LHGDN CLL, but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium. 15731179

2005

Entrez Id: 921
Gene Symbol: CD5
CD5
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 GeneticVariation LHGDN We studied the presence of MSI in the CD5 promoter in 134 cases of B-cell chronic lymphocytic leukemia (B-CLL) and 47 of mantle cell lymphoma (MCL) by comparing the pattern of microsatellite repeats on autologous germline and tumor DNA samples. 15981803

2005

Entrez Id: 330
Gene Symbol: BIRC3
BIRC3
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 AlteredExpression LHGDN Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia. 15183896

2004

Entrez Id: 3676
Gene Symbol: ITGA4
ITGA4
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 Biomarker LHGDN Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine. 14623330

2003

Entrez Id: 921
Gene Symbol: CD5
CD5
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 GeneticVariation LHGDN CD5-negative, CD10-negative small B-cell leukemia: variant of chronic lymphocytic leukemia or a distinct entity? 12447961

2002

Entrez Id: 3676
Gene Symbol: ITGA4
ITGA4
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.400 Biomarker LHGDN The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. 11929789

2002

Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.330 Biomarker LHGDN Since IL-8 has been implicated in progression of B-CLL disease, our findings suggest that, by upregulating IL-8, the RANKL/RANK system may contribute to the pathogenesis of B-CLL. 16270354

2006