Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker CTD_human Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. 24816253

2014

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker CTD_human Silencing of CDH1 by promoter CpG island methylation was shown in gastric cancer, precancerous lesion, and Helicobacter pylori-infected chronic gastritis. 19184424

2010

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker CTD_human We hypothesized that CDH1 genomic rearrangements would be found in HDGC and identified 160 families with either two gastric cancers in first-degree relatives and with at least one diffuse gastric cancer (DGC) diagnosed before age 50, or three or more DGC in close relatives diagnosed at any age. 19168852

2009

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker CTD_human We screened a series of 66 young gastric cancer probands for germline CDH1 mutations, and two novel missense alterations together with an intronic variant were identified. 12588804

2003

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker CTD_human However, only a minority of familial gastric cancers can be accounted for by CDH1 mutations. 10072428

1999

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker CTD_human E-cadherin germline mutations in familial gastric cancer. 9537325

1998

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. 22484628

2012

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human Crizotinib thus shows a marked antitumor action both in vitro and in vivo specifically in gastric cancer cells positive for MET amplification. 22729845

2012

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human Thus, combined expression of MYC, EGFR and FGFR2 is predictive of poor survival in CF-treated metastatic gastric cancer patients. 21173787

2012

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947

2011

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human We analyzed the association between HER2 overexpression and the clinicopathologic characteristics of advanced GC. 21532492

2011

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human High dose fluorouracil/leucovorin-based chemotherapy may have the potential to reverse the adverse effects resulting from erbB2 gene amplification in gastric cancer. 15640503

2004

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human

Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.660 Biomarker CTD_human

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.660 Biomarker CTD_human

Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.640 Biomarker CTD_human

Entrez Id: 843
Gene Symbol: CASP10
CASP10
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.610 Biomarker CTD_human

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker CTD_human We found a new gastric cancer association with loss-of-function mutations in ATM (gene test, P = 8.0 × 10(-12); odds ratio (OR) = 4.74). 26098866

2015

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1. 26098866

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human Moderate to high Cap consumption synergistically increased GC risk in genetically susceptible individuals (IL1B-31C allele carriers) infected with the more virulent H. pylori (CagA+) strains. 22414649

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human The effects of interleukin-1beta (IL-1beta) and epigenetic mechanisms on 15-PGDH regulation were assessed in gastric cancer cell lines. 19584167

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human Implication of peroxisome proliferator-activated receptor gamma and proinflammatory cytokines in gastric carcinogenesis: link to Helicobacter pylori-infection. 15492468

2004

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years. 11397402

2001